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    Ifi27l2b interferon, alpha-inducible protein 27 like 2B [ Mus musculus (house mouse) ]

    Gene ID: 217845, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ifi27l2bprovided by MGI
    Official Full Name
    interferon, alpha-inducible protein 27 like 2Bprovided by MGI
    Primary source
    MGI:MGI:1916390
    See related
    Ensembl:ENSMUSG00000021208 AllianceGenome:MGI:1916390
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ISG12(b2); 1810023F06Rik
    Summary
    Enables identical protein binding activity. Involved in intrinsic apoptotic signaling pathway. Located in mitochondrial inner membrane. Orthologous to several human genes including IFI27L2 (interferon alpha inducible protein 27 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in duodenum adult (RPKM 471.2), small intestine adult (RPKM 461.9) and 3 other tissues See more
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    Genomic context

    See Ifi27l2b in Genome Data Viewer
    Location:
    12 E; 12 52.93 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103417157..103423482, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103450898..103457223, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2393 Neighboring gene STARR-seq mESC enhancer starr_33125 Neighboring gene predicted gene, 53758 Neighboring gene STARR-positive B cell enhancer ABC_E2394 Neighboring gene interferon, alpha-inducible protein 27 like 2A Neighboring gene interferon, alpha-inducible protein 27 Neighboring gene predicted gene, 53759 Neighboring gene STARR-positive B cell enhancer ABC_E7175 Neighboring gene protein phosphatase 4, regulatory subunit 4 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in release of cytochrome c from mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    interferon alpha-inducible protein 27-like protein 2B
    Names
    interferon stimulated gene 12(b2)
    interferon-stimulated gene 12 protein B2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145449.2NP_663424.1  interferon alpha-inducible protein 27-like protein 2B precursor

      See identical proteins and their annotated locations for NP_663424.1

      Status: VALIDATED

      Source sequence(s)
      AC154347, AK007590, BN000232
      Consensus CDS
      CCDS26133.1
      UniProtKB/Swiss-Prot
      Q6IEB6, Q8VC49
      Related
      ENSMUSP00000041712.7, ENSMUST00000044687.7
      Conserved Domains (1) summary
      pfam06140
      Location:1288
      Ifi-6-16; Interferon-induced 6-16 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      103417157..103423482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515758.2XP_006515821.1  interferon alpha-inducible protein 27-like protein 2B isoform X1

      Conserved Domains (1) summary
      pfam06140
      Location:1279
      Ifi-6-16; Interferon-induced 6-16 family