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    Serpina10 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 [ Mus musculus (house mouse) ]

    Gene ID: 217847, updated on 9-Dec-2024

    Summary

    Official Symbol
    Serpina10provided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10provided by MGI
    Primary source
    MGI:MGI:2667725
    See related
    Ensembl:ENSMUSG00000061947 AllianceGenome:MGI:2667725
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PZI; ZPI
    Summary
    The protein encoded by this gene is a member of the large serpin family of proteins, and is also known as serpin PZ-dependent protease inhibitor (ZPI or PZI). This protein is thought to play an important role in the regulation of coagulation. It directly inhibits factor XIa, and also inhibits factor Xa in the presence of calcium, phospholipids, and protein Z (PZ). Deficiencies in this gene lead to an increase in thrombosis. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Aug 2014]
    Expression
    Biased expression in liver E18 (RPKM 38.8), liver adult (RPKM 34.0) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Serpina10 in Genome Data Viewer
    Location:
    12 E; 12 52.97 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103582934..103597681, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103616675..103631490, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53759 Neighboring gene interferon, alpha-inducible protein 27 like 2B Neighboring gene STARR-positive B cell enhancer ABC_E7175 Neighboring gene protein phosphatase 4, regulatory subunit 4 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Clone Names

    • MGC25863

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in liver regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein Z-dependent protease inhibitor
    Names
    PZ-dependent protease inhibitor
    serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301404.2NP_001288333.1  protein Z-dependent protease inhibitor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001288333.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AC125360, AI591819, AK050552
      Consensus CDS
      CCDS79150.1
      UniProtKB/Swiss-Prot
      Q8R121
      Related
      ENSMUSP00000113644.2, ENSMUST00000121625.2
      Conserved Domains (1) summary
      cl00137
      Location:78388
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    2. NM_144834.5NP_659083.2  protein Z-dependent protease inhibitor isoform 1 precursor

      See identical proteins and their annotated locations for NP_659083.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC125360, AI591819, AK050552
      Consensus CDS
      CCDS26134.1
      UniProtKB/Swiss-Prot
      Q8R121, Q8VCV8
      Related
      ENSMUSP00000048357.6, ENSMUST00000044231.12
      Conserved Domains (1) summary
      cl00137
      Location:78442
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    RNA

    1. NR_182064.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC125360

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      103582934..103597681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)