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    Phf5a PHD finger protein 5A [ Mus musculus (house mouse) ]

    Gene ID: 68479, updated on 9-Dec-2024

    Summary

    Official Symbol
    Phf5aprovided by MGI
    Official Full Name
    PHD finger protein 5Aprovided by MGI
    Primary source
    MGI:MGI:2156864
    See related
    Ensembl:ENSMUSG00000061360 AllianceGenome:MGI:2156864
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110007B08Rik
    Summary
    Predicted to enable RNA binding activity and zinc ion binding activity. Involved in stem cell differentiation. Located in nuclear matrix and nuclear speck. Is expressed in several structures, including brain; branchial arch; embryo mesenchyme; maxillary process; and sensory organ. Orthologous to human PHF5A (PHD finger protein 5A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 43.6), CNS E11.5 (RPKM 39.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Phf5a in Genome Data Viewer
    Location:
    15 E1; 15 38.26 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81748717..81756093, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81864516..81871892, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8599 Neighboring gene predicted gene 8444 Neighboring gene STARR-positive B cell enhancer ABC_E7399 Neighboring gene STARR-positive B cell enhancer ABC_E481 Neighboring gene transducer of ERBB2, 2 Neighboring gene aconitase 2, mitochondrial Neighboring gene STARR-seq mESC enhancer starr_39272 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide H Neighboring gene STARR-positive B cell enhancer ABC_E2447 Neighboring gene cold shock domain containing C2, RNA binding

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation
    • Transgenic (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in stem cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of U12-type spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of U12-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of U2 snRNP ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U2 snRNP ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of U2-type precatalytic spliceosome IEA
    Inferred from Electronic Annotation
    more info
     
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U2-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    PHD finger-like domain-containing protein 5A
    Names
    PHD finger-like domain protein 5A
    SF3b14b
    splicing factor 3B-associated 14 kDa protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026737.3NP_081013.1  PHD finger-like domain-containing protein 5A

      See identical proteins and their annotated locations for NP_081013.1

      Status: PROVISIONAL

      Source sequence(s)
      AK143590
      Consensus CDS
      CCDS27674.1
      UniProtKB/Swiss-Prot
      P83870, Q3TQX7
      Related
      ENSMUSP00000023117.9, ENSMUST00000023117.10
      Conserved Domains (1) summary
      pfam03660
      Location:1104
      PHF5; PHF5-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      81748717..81756093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)