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    Sumo2 small ubiquitin-like modifier 2 [ Mus musculus (house mouse) ]

    Gene ID: 170930, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sumo2provided by MGI
    Official Full Name
    small ubiquitin-like modifier 2provided by MGI
    Primary source
    MGI:MGI:2158813
    See related
    Ensembl:ENSMUSG00000020738 AllianceGenome:MGI:2158813
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Smt3A; Smt3b; SUMO-2; Smt3h2
    Summary
    Enables SUMO transferase activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II and protein sumoylation. Is active in several cellular components, including hippocampal mossy fiber to CA3 synapse; postsynaptic cytosol; and presynaptic cytosol. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; eye; and heart. Orthologous to human SUMO2 (small ubiquitin like modifier 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 246.7), CNS E14 (RPKM 206.8) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Sumo2 in Genome Data Viewer
    Location:
    11 E2; 11 80.84 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115413935..115427056, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115523109..115536230, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115353318-115353427 Neighboring gene ribosomal protein L39 pseudogene Neighboring gene 5',3'-nucleotidase, cytosolic Neighboring gene Jupiter microtubule associated homolog 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115374372-115374555 Neighboring gene STARR-positive B cell enhancer ABC_E470 Neighboring gene STARR-positive B cell enhancer ABC_E4015 Neighboring gene STARR-seq mESC enhancer starr_31164 Neighboring gene STARR-positive B cell enhancer ABC_E8882 Neighboring gene nucleoporin 85 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 3 Neighboring gene predicted gene, 25364

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear retinoid X receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin-like protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in GABA-ergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in PML body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in hippocampal mossy fiber to CA3 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in hippocampal mossy fiber to CA3 synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in postsynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    small ubiquitin-related modifier 2
    Names
    SMT3 homolog 2
    SMT3 suppressor of mif two 3 homolog 2
    SMT3 supressor of mif two 3 homolog 2
    sentrin-2
    ubiquitin-like protein SMT3A
    ubiquitin-like protein SMT3B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133354.2NP_579932.1  small ubiquitin-related modifier 2

      See identical proteins and their annotated locations for NP_579932.1

      Status: PROVISIONAL

      Source sequence(s)
      AK012619
      Consensus CDS
      CCDS36374.1
      UniProtKB/Swiss-Prot
      A2A9X2, P61957, Q542L8
      Related
      ENSMUSP00000115044.2, ENSMUST00000153892.2
      Conserved Domains (1) summary
      cd16115
      Location:1788
      Ubl_SUMO2_3_4; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier SUMO-2, SUMO-3, SUMO-4, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115413935..115427056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)