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    Adap1 ArfGAP with dual PH domains 1 [ Mus musculus (house mouse) ]

    Gene ID: 231821, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Adap1provided by MGI
    Official Full Name
    ArfGAP with dual PH domains 1provided by MGI
    Primary source
    MGI:MGI:2442201
    See related
    Ensembl:ENSMUSG00000056413 AllianceGenome:MGI:2442201
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GC1L; Centa1; p42IP4; 4930431P11Rik
    Summary
    Predicted to enable GTPase activator activity; inositol 1,3,4,5 tetrakisphosphate binding activity; and phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and plasma membrane. Is expressed in nervous system. Orthologous to human ADAP1 (ArfGAP with dual PH domains 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in duodenum adult (RPKM 78.3), large intestine adult (RPKM 65.2) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adap1 in Genome Data Viewer
    Location:
    5 G2; 5 78.27 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (139257631..139311516, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (139271876..139325763, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14686 Neighboring gene STARR-seq mESC enhancer starr_14687 Neighboring gene Sad1 and UNC84 domain containing 1 Neighboring gene golgi to ER traffic protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E4802 Neighboring gene STARR-positive B cell enhancer ABC_E2770 Neighboring gene STARR-positive B cell enhancer ABC_E6389 Neighboring gene STARR-positive B cell enhancer ABC_E9266 Neighboring gene STARR-positive B cell enhancer ABC_E8825 Neighboring gene STARR-positive B cell enhancer ABC_E6390 Neighboring gene cytochrome c oxidase assembly protein 19 Neighboring gene cytochrome P450, family 2, subfamily w, polypeptide 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ADAP1/Centaurin-α1 Negatively Regulates Dendritic Spine Function and Memory Formation in the Hippocampus. Szatmari EM, et al. eNeuro, 2021 Jan-Feb. PMID 33139322, Free PMC Article
    2. ADAP1 promotes invasive squamous cell carcinoma progression and predicts patient survival. Van Duzer A, et al. Life Sci Alliance, 2019 Dec. PMID 31792062, Free PMC Article
    3. Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation. Khang R, et al. Sci Rep, 2021 Nov 23. PMID 34815492, Free PMC Article
    4. The LMO2 oncogene regulates DNA replication in hematopoietic cells. Sincennes MC, et al. Proc Natl Acad Sci U S A, 2016 Feb 2. PMID 26764384, Free PMC Article
    5. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADAP1/Centaurin-alpha1 Negatively Regulates Dendritic Spine Function and Memory Formation in the Hippocampus.
      Title: ADAP1/Centaurin-α1 Negatively Regulates Dendritic Spine Function and Memory Formation in the Hippocampus.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol 1,3,4,5 tetrakisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP with dual PH domain-containing protein 1
    Names
    centaurin, alpha 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172723.4 → NP_766311.2  arf-GAP with dual PH domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      BC079634, BY740716, CX242691
      Consensus CDS
      CCDS19806.2
      UniProtKB/TrEMBL
      E9PY16, Q6PGM4
      Related
      ENSMUSP00000106489.2, ENSMUST00000110865.2
      Conserved Domains (3) summary
      smart00105
      Location:10 → 126
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd01251
      Location:252 → 357
      PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
      cd13252
      Location:130 → 238
      PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      139257631..139311516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504669.4 → XP_006504732.1  arf-GAP with dual PH domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006504732.1

      UniProtKB/TrEMBL
      Q6PGM4, Q8BVR8
      Conserved Domains (3) summary
      cd01251
      Location:180 → 285
      PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
      cd13252
      Location:58 → 166
      PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
      cl28907
      Location:1 → 41
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    Nucleotide Protein Strain
    Heading Accession and Version

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