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    Tmem106b transmembrane protein 106B [ Mus musculus (house mouse) ]

    Gene ID: 71900, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmem106bprovided by MGI
    Official Full Name
    transmembrane protein 106Bprovided by MGI
    Primary source
    MGI:MGI:1919150
    See related
    Ensembl:ENSMUSG00000029571 AllianceGenome:MGI:1919150
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310036D22Rik; 5830455K21Rik; 6430519M21Rik
    Summary
    Enables ATPase binding activity. Acts upstream of or within several processes, including lysosomal lumen acidification; lysosomal protein catabolic process; and positive regulation of dendrite development. Located in lysosome. Is expressed in several structures, including alimentary system; hemolymphoid system gland; integumental system; male reproductive gland or organ; and nervous system. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 16. Orthologous to human TMEM106B (transmembrane protein 106B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 21.1), bladder adult (RPKM 15.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Tmem106b in Genome Data Viewer
    Location:
    6 A1; 6 5.38 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (13069758..13089268)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (13069759..13089269)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15188 Neighboring gene predicted gene, 18221 Neighboring gene STARR-positive B cell enhancer ABC_E10369 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_15191 Neighboring gene predicted gene, 24985 Neighboring gene von Willebrand factor D and EGF domains

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dendrite morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within lysosomal lumen acidification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lysosomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lysosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within lysosomal transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lysosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lysosome localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lysosome localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lysosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within lysosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of lysosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027992.3NP_082268.2  transmembrane protein 106B

      See identical proteins and their annotated locations for NP_082268.2

      Status: VALIDATED

      Source sequence(s)
      AI552875, AK078219, AK148477, BC050246, BP760304, BQ888115, CA751076, CD776556
      Consensus CDS
      CCDS19914.1
      UniProtKB/Swiss-Prot
      Q80X71, Q9D737
      Related
      ENSMUSP00000031556.8, ENSMUST00000031556.14
      Conserved Domains (1) summary
      pfam07092
      Location:34259
      DUF1356; Protein of unknown function (DUF1356)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      13069758..13089268
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505169.5XP_006505232.1  transmembrane protein 106B isoform X1

      See identical proteins and their annotated locations for XP_006505232.1

      UniProtKB/Swiss-Prot
      Q80X71, Q9D737
      Conserved Domains (1) summary
      pfam07092
      Location:34259
      DUF1356; Protein of unknown function (DUF1356)