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    Pon3 paraoxonase 3 [ Mus musculus (house mouse) ]

    Gene ID: 269823, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pon3provided by MGI
    Official Full Name
    paraoxonase 3provided by MGI
    Primary source
    MGI:MGI:106686
    See related
    Ensembl:ENSMUSG00000029759 AllianceGenome:MGI:106686
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810004E20
    Summary
    Predicted to enable carboxylic ester hydrolase activity and protein homodimerization activity. Involved in negative regulation of superoxide anion generation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; and atherosclerosis. Orthologous to human PON3 (paraoxonase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 16.0), bladder adult (RPKM 15.5) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Pon3 in Genome Data Viewer
    Location:
    6 A1; 6 1.99 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (5216253..5256236, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (5216256..5256285, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 9A Neighboring gene predicted gene, 46949 Neighboring gene STARR-seq mESC enhancer starr_15033 Neighboring gene paraoxonase 1 Neighboring gene STARR-positive B cell enhancer ABC_E3642 Neighboring gene STARR-seq mESC enhancer starr_15035 Neighboring gene STARR-positive B cell enhancer ABC_E8094 Neighboring gene paraoxonase 2 Neighboring gene STARR-seq mESC enhancer starr_15037 Neighboring gene predicted gene, 38762

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyl-L-homoserine-lactone lactonohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acyl-L-homoserine-lactone lactonohydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables aryldialkylphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables arylesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables arylesterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables arylesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dihydrocoumarin hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in carboxylic acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in carboxylic acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in coumarin catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of establishment of localization in cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of establishment of localization in cell IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in lactone catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lactone catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of superoxide anion generation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phenylacetate catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cellular response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cellular response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of renal sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of renal sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of renal sodium ion transport IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in response to toxic substance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serum paraoxonase/lactonase 3
    NP_001350741.1
    NP_001398668.1
    NP_001398669.1
    NP_001398670.1
    NP_001398671.1
    NP_001398672.1
    NP_001398673.1
    NP_001398674.1
    NP_766594.1
    XP_036022087.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363812.2NP_001350741.1  serum paraoxonase/lactonase 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164289
      Conserved Domains (1) summary
      pfam01731
      Location:94179
      Arylesterase
    2. NM_001411739.1NP_001398668.1  serum paraoxonase/lactonase 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164289
    3. NM_001411740.1NP_001398669.1  serum paraoxonase/lactonase 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164289
    4. NM_001411741.1NP_001398670.1  serum paraoxonase/lactonase 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164289
    5. NM_001411742.1NP_001398671.1  serum paraoxonase/lactonase 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC164289
      Related
      ENSMUST00000156848.8
    6. NM_001411743.1NP_001398672.1  serum paraoxonase/lactonase 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC164289
    7. NM_001411744.1NP_001398673.1  serum paraoxonase/lactonase 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC164289
    8. NM_001411745.1NP_001398674.1  serum paraoxonase/lactonase 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC164289
    9. NM_173006.3NP_766594.1  serum paraoxonase/lactonase 3 isoform 1

      See identical proteins and their annotated locations for NP_766594.1

      Status: VALIDATED

      Source sequence(s)
      AC164289
      Consensus CDS
      CCDS19899.1
      UniProtKB/Swiss-Prot
      Q4FZK0, Q62087, Q8C2I7
      Related
      ENSMUSP00000031773.3, ENSMUST00000031773.9
      Conserved Domains (1) summary
      pfam01731
      Location:167252
      Arylesterase; Arylesterase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      5216253..5256236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166194.1XP_036022087.1  serum paraoxonase/lactonase 3 isoform X1

      Conserved Domains (1) summary
      pfam01731
      Location:94179
      Arylesterase