U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pdyn prodynorphin [ Mus musculus (house mouse) ]

    Gene ID: 18610, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pdynprovided by MGI
    Official Full Name
    prodynorphinprovided by MGI
    Primary source
    MGI:MGI:97535
    See related
    Ensembl:ENSMUSG00000027400 AllianceGenome:MGI:97535
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dyn
    Summary
    This gene encodes a preproprotein that is proteolytically cleaved to yield a number of active opium-like peptides. These peptides are the endogenous ligands for the Kappa-opioid receptor and similar G-protein-coupled receptors and are thought to function as the body's natural way to control addiction. These peptides have been associated with depression, stress, anxiety, response to pain, and maintenance of homeostasis via circadian rhythms and control of appetite. Mutations in the related human gene have been linked to the neurodegenerative disease spinocerebellar ataxia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
    Expression
    Biased expression in cortex adult (RPKM 4.6), CNS E18 (RPKM 3.1) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pdyn in Genome Data Viewer
    Location:
    2 F1; 2 63.19 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (129528469..129541858, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (129686549..129699938, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14041 Neighboring gene STARR-seq mESC enhancer starr_05675 Neighboring gene signal-regulatory protein alpha Neighboring gene STARR-seq mESC enhancer starr_05676 Neighboring gene STARR-seq mESC enhancer starr_05677 Neighboring gene STARR-seq mESC enhancer starr_05678 Neighboring gene STARR-seq mESC enhancer starr_05679 Neighboring gene peptidylprolyl isomerase A (Ppia) pseudogene 2_1620.1 Neighboring gene STARR-seq mESC enhancer starr_05680 Neighboring gene serine/threonine kinase 35, opposite strand 1 Neighboring gene serine/threonine kinase 35

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables neuropeptide hormone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables opioid peptide activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables opioid receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensory perception IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in axon terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dense core granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in hippocampal mossy fiber to CA3 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuronal dense core vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuronal dense core vesicle lumen ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    proenkephalin-B
    Names
    alpha-neoendorphin
    beta-neoendorphin
    beta-neoendorphin-dynorphin
    big dynorphin
    dynorphin A(1-13)
    dynorphin A(1-17)
    dynorphin A(1-8)
    leu-enkephalin
    leumorphin
    preprodynorphin
    rimorphin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286502.1NP_001273431.1  proenkephalin-B preproprotein

      See identical proteins and their annotated locations for NP_001273431.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK133597, AL808137, BB421226, BY292284
      Consensus CDS
      CCDS38239.1
      UniProtKB/TrEMBL
      O35852, Q3UZW2
      Conserved Domains (1) summary
      pfam01160
      Location:2268
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
    2. NM_018863.4NP_061351.2  proenkephalin-B preproprotein

      See identical proteins and their annotated locations for NP_061351.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK133597, AL808137, BB421226
      Consensus CDS
      CCDS38239.1
      UniProtKB/TrEMBL
      O35852, Q3UZW2
      Related
      ENSMUSP00000028883.6, ENSMUST00000028883.12
      Conserved Domains (1) summary
      pfam01160
      Location:2268
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      129528469..129541858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)