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    Igll1 immunoglobulin lambda-like polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 16136, updated on 9-Dec-2024

    Summary

    Official Symbol
    Igll1provided by MGI
    Official Full Name
    immunoglobulin lambda-like polypeptide 1provided by MGI
    Primary source
    MGI:MGI:96529
    See related
    Ensembl:ENSMUSG00000075370 AllianceGenome:MGI:96529
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Igll; Igl-5; Lambda5
    Summary
    Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be located in endoplasmic reticulum and extracellular region. Predicted to be part of IgG immunoglobulin complex. Is expressed in bone marrow; embryo; lesser omentum; liver; and yolk sac. Human ortholog(s) of this gene implicated in agammaglobulinemia 2. Orthologous to several human genes including IGLL1 (immunoglobulin lambda like polypeptide 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E18 (RPKM 12.8), liver E14.5 (RPKM 0.9) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Igll1 in Genome Data Viewer
    Location:
    16 A3; 16 10.45 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (16678535..16681849, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (16860671..16863985, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene stress-induced phosphoprotein 1 pseudogene Neighboring gene nuclear encoded tRNA lysine 3 (anticodon CTT) Neighboring gene STARR-seq mESC enhancer starr_40238 Neighboring gene V-set pre-B cell surrogate light chain 1A Neighboring gene topoisomerase (DNA) III beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in immunoglobulin mediated immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of IgG immunoglobulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    immunoglobulin lambda-like polypeptide 1
    Names
    CD179 antigen-like family member B
    ig lambda-5
    immunoglobulin lambda chain 5
    lambda 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190325.1NP_001177254.1  immunoglobulin lambda-like polypeptide 1 precursor

      See identical proteins and their annotated locations for NP_001177254.1

      Status: VALIDATED

      Source sequence(s)
      AC166832
      Consensus CDS
      CCDS49775.1
      UniProtKB/Swiss-Prot
      E9QMX0, P20764, Q5W1K3
      Related
      ENSMUSP00000097713.4, ENSMUST00000100136.4
      Conserved Domains (1) summary
      cd07699
      Location:110207
      IgC_L; Immunoglobulin Constant domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      16678535..16681849 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)