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    Nkx2-9 NK2 homeobox 9 [ Mus musculus (house mouse) ]

    Gene ID: 18094, updated on 27-Nov-2024

    Summary

    Official Symbol
    Nkx2-9provided by MGI
    Official Full Name
    NK2 homeobox 9provided by MGI
    Primary source
    MGI:MGI:1270158
    See related
    Ensembl:ENSMUSG00000058669 AllianceGenome:MGI:1270158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nkx2-8; Nkx2.9; tinman; Nkx-2.9
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within axonogenesis; lung development; and negative regulation of epithelial cell proliferation. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; embryo mesoderm; liver; and lung epithelium. Orthologous to human NKX2-8 (NK2 homeobox 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 1.1), CNS E11.5 (RPKM 0.9) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nkx2-9 in Genome Data Viewer
    Location:
    12 C1; 12 24.47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (56658174..56660354, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (56611389..56613569, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32210 Neighboring gene predicted gene, 25760 Neighboring gene STARR-seq mESC enhancer starr_32211 Neighboring gene expressed sequence C87198 Neighboring gene STARR-seq mESC enhancer starr_32212 Neighboring gene STARR-seq mESC enhancer starr_32213 Neighboring gene predicted gene, 26973 Neighboring gene transcriptional adaptor 1 pseudogene Neighboring gene predicted gene 15524 Neighboring gene paired box 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    homeobox protein Nkx-2.8
    Names
    Drosophila NK2 transcription factor related, locus 9
    NK2 transcription factor related, locus 9
    homeobox protein NK-2 homolog H
    homeobox protein Nkx-2.9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008701.2NP_032727.2  homeobox protein Nkx-2.8

      See identical proteins and their annotated locations for NP_032727.2

      Status: VALIDATED

      Source sequence(s)
      AC160393
      Consensus CDS
      CCDS25923.1
      UniProtKB/Swiss-Prot
      B2RWY9, O70584
      Related
      ENSMUSP00000072425.6, ENSMUST00000072631.6
      Conserved Domains (1) summary
      pfam00046
      Location:84138
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      56658174..56660354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515533.4XP_006515596.1  homeobox protein Nkx-2.8 isoform X1

      See identical proteins and their annotated locations for XP_006515596.1

      UniProtKB/Swiss-Prot
      B2RWY9, O70584
      Conserved Domains (1) summary
      pfam00046
      Location:84138
      Homeobox; Homeobox domain