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    Hyou1 hypoxia up-regulated 1 [ Mus musculus (house mouse) ]

    Gene ID: 12282, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hyou1provided by MGI
    Official Full Name
    hypoxia up-regulated 1provided by MGI
    Primary source
    MGI:MGI:108030
    See related
    Ensembl:ENSMUSG00000032115 AllianceGenome:MGI:108030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cab140; Grp170; Orp150; CBP-140
    Summary
    Predicted to enable adenyl-nucleotide exchange factor activity. Involved in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway and response to ischemia. Part of endoplasmic reticulum chaperone complex. Is expressed in cerebral cortex subventricular zone; cortical plate; embryo; and tail. Human ortholog(s) of this gene implicated in immunodeficiency 59. Orthologous to human HYOU1 (hypoxia up-regulated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 39.8), placenta adult (RPKM 37.7) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Hyou1 in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44290840..44303662)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44379490..44392369)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40516 Neighboring gene predicted gene 10080 Neighboring gene STARR-positive B cell enhancer ABC_E1785 Neighboring gene STARR-positive B cell enhancer ABC_E5063 Neighboring gene predicted gene, 26306 Neighboring gene solute carrier family 37 (glucose-6-phosphate transporter), member 4 Neighboring gene microRNA 7085

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to ischemia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to ischemia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of endoplasmic reticulum chaperone complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of endoplasmic reticulum chaperone complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hypoxia up-regulated protein 1
    Names
    140 kDa Ca(2+)-binding protein
    150-kDa oxygen regulated protein
    170 kDa glucose regulated protein GRP170
    GRP-170
    calcium binding protein 140
    calcium binding protein, 140 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411630.1NP_001398559.1  hypoxia up-regulated protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC122428
    2. NM_001411631.1NP_001398560.1  hypoxia up-regulated protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC122428
    3. NM_021395.5NP_067370.3  hypoxia up-regulated protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_067370.3

      Status: VALIDATED

      Source sequence(s)
      AC122428
      Consensus CDS
      CCDS23107.1
      UniProtKB/Swiss-Prot
      Q3TAL1, Q3TZD0, Q3U1U2, Q64139, Q80X75, Q9JKR6
      Related
      ENSMUSP00000068594.7, ENSMUST00000066601.13
      Conserved Domains (3) summary
      cd10230
      Location:36424
      HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
      PHA03169
      Location:586691
      PHA03169; hypothetical protein; Provisional
      COG5271
      Location:554767
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44290840..44303662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509960.4XP_006510023.1  hypoxia up-regulated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006510023.1

      UniProtKB/Swiss-Prot
      Q3TAL1, Q3TZD0, Q3U1U2, Q64139, Q80X75, Q9JKR6
      Related
      ENSMUSP00000123700.2, ENSMUST00000161318.8
      Conserved Domains (3) summary
      cd10230
      Location:36424
      HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
      PHA03169
      Location:586691
      PHA03169; hypothetical protein; Provisional
      COG5271
      Location:554767
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    2. XM_006509961.4XP_006510024.1  hypoxia up-regulated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006510024.1

      UniProtKB/Swiss-Prot
      Q3TAL1, Q3TZD0, Q3U1U2, Q64139, Q80X75, Q9JKR6
      Conserved Domains (3) summary
      cd10230
      Location:36424
      HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
      PHA03169
      Location:586691
      PHA03169; hypothetical protein; Provisional
      COG5271
      Location:554767
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    3. XM_006509959.4XP_006510022.1  hypoxia up-regulated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006510022.1

      UniProtKB/Swiss-Prot
      Q3TAL1, Q3TZD0, Q3U1U2, Q64139, Q80X75, Q9JKR6
      Related
      ENSMUSP00000125594.2, ENSMUST00000160902.8
      Conserved Domains (3) summary
      cd10230
      Location:36424
      HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
      PHA03169
      Location:586691
      PHA03169; hypothetical protein; Provisional
      COG5271
      Location:554767
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    4. XM_006509962.4XP_006510025.1  hypoxia up-regulated protein 1 isoform X2

      Conserved Domains (2) summary
      cd10230
      Location:36424
      HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
      PHA00666
      Location:597760
      PHA00666; putative protease