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    Lrpap1 low density lipoprotein receptor-related protein associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 16976, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lrpap1provided by MGI
    Official Full Name
    low density lipoprotein receptor-related protein associated protein 1provided by MGI
    Primary source
    MGI:MGI:96829
    See related
    Ensembl:ENSMUSG00000029103 AllianceGenome:MGI:96829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RAP; HBP44
    Summary
    Enables low-density lipoprotein particle receptor binding activity. Predicted to be involved in several processes, including amyloid-beta clearance by transcytosis; negative regulation of amyloid-beta clearance; and negative regulation of very-low-density lipoprotein particle clearance. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and vesicle. Predicted to be active in several cellular components, including cis-Golgi network; endoplasmic reticulum-Golgi intermediate compartment; and rough endoplasmic reticulum lumen. Is expressed in several structures, including central nervous system; egg cylinder; foregut; genitourinary system; and lung. Human ortholog(s) of this gene implicated in Alzheimer's disease; dementia; myocardial infarction; and myopia. Orthologous to human LRPAP1 (LDL receptor related protein associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 78.1), placenta adult (RPKM 64.3) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lrpap1 in Genome Data Viewer
    Location:
    5 B2; 5 18.01 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (35248834..35263043, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (35091490..35105699, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene hepatocyte growth factor activator Neighboring gene docking protein 7 Neighboring gene STARR-seq mESC enhancer starr_12851 Neighboring gene STARR-positive B cell enhancer ABC_E3569 Neighboring gene STARR-seq mESC enhancer starr_12852 Neighboring gene predicted gene, 31601 Neighboring gene STARR-seq mESC enhancer starr_12853 Neighboring gene predicted gene, 40281

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lipase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables low-density lipoprotein particle receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables low-density lipoprotein particle receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables receptor antagonist activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables receptor antagonist activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor antagonist activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor ligand activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables very-low-density lipoprotein particle receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables very-low-density lipoprotein particle receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables very-low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in amyloid-beta clearance by transcytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amyloid-beta clearance by transcytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of amyloid-beta clearance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of amyloid-beta clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of very-low-density lipoprotein particle clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of very-low-density lipoprotein particle clearance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of very-low-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of receptor-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Golgi lumen IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cis-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cis-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endosome lumen IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in rough endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in rough endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
     
    located_in rough endoplasmic reticulum lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    alpha-2-macroglobulin receptor-associated protein
    Names
    alpha-2-MRAP
    alpha-2-macroglobulin receptor-associated protein precursor (alpha-2-MRAP)
    heparin-binding protein 44

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013587.3NP_038615.2  alpha-2-macroglobulin receptor-associated protein precursor

      See identical proteins and their annotated locations for NP_038615.2

      Status: VALIDATED

      Source sequence(s)
      BC094324, BY642418, BY771772
      Consensus CDS
      CCDS19225.1
      UniProtKB/Swiss-Prot
      P55302
      UniProtKB/TrEMBL
      Q3TL96, Q52KI7, Q5D0B0, Q6ZY49, Q8C252
      Related
      ENSMUSP00000030986.9, ENSMUST00000030986.15
      Conserved Domains (5) summary
      cd14806
      Location:6170
      RAP_D1; 3-helical coiled coil [structural motif]
      cd14807
      Location:149246
      RAP_D2; Domain 2 of receptor-associated protein (RAP)
      cd14808
      Location:255360
      RAP_D3; C-terminal receptor-associated protein (RAP), Domain 3
      pfam06400
      Location:31134
      Alpha-2-MRAP_N; Alpha-2-macroglobulin RAP, N-terminal domain
      pfam06401
      Location:149360
      Alpha-2-MRAP_C; Alpha-2-macroglobulin RAP, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      35248834..35263043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)