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    Fndc1 fibronectin type III domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 68655, updated on 3-Dec-2024

    Summary

    Official Symbol
    Fndc1provided by MGI
    Official Full Name
    fibronectin type III domain containing 1provided by MGI
    Primary source
    MGI:MGI:1915905
    See related
    Ensembl:ENSMUSG00000071984 AllianceGenome:MGI:1915905
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1866; 1110027O12Rik; 1110051A18Rik
    Summary
    Predicted to act upstream of or within several processes, including cellular response to hypoxia; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of protein phosphorylation. Predicted to be located in cell-cell junction; mitochondrial membrane; and plasma membrane. Is expressed in alimentary system; dermis; embryo mesenchyme; eye; and salivary gland primordium. Orthologous to human FNDC1 (fibronectin type III domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 10.6), limb E14.5 (RPKM 9.5) and 15 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fndc1 in Genome Data Viewer
    Location:
    17 A1; 17 4.77 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (7957401..8046158, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (7738569..7827340, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33086 Neighboring gene predicted gene, 33158 Neighboring gene STARR-seq mESC enhancer starr_41759 Neighboring gene adaptor-related protein complex 3, sigma 1 subunit pseudogene Neighboring gene expressed sequence AU041480 Neighboring gene predicted gene 1604A Neighboring gene T cell activation Rho GTPase activating protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Spontaneous (1)  1 citation
    • Targeted (1) 

    General protein information

    Preferred Names
    fibronectin type III domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081416.3NP_001074885.2  fibronectin type III domain-containing protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164983
      Consensus CDS
      CCDS37431.1
      UniProtKB/TrEMBL
      A0A8V5KYN9, E9Q043
      Related
      ENSMUSP00000159498.1, ENSMUST00000240702.1
      Conserved Domains (3) summary
      smart00060
      Location:103186
      FN3; Fibronectin type 3 domain
      PHA03247
      Location:5841157
      PHA03247; large tegument protein UL36; Provisional
      cd00063
      Location:307397
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. NM_001403750.1NP_001390679.1  fibronectin type III domain-containing protein 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164983
      UniProtKB/TrEMBL
      A0A6I8MWX0, E9Q043
      Related
      ENSMUSP00000159298.2, ENSMUST00000239425.2
    3. NM_001403751.1NP_001390680.1  fibronectin type III domain-containing protein 1 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164983
      UniProtKB/TrEMBL
      E9Q043
    4. NM_001403752.1NP_001390681.1  fibronectin type III domain-containing protein 1 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164983
      UniProtKB/TrEMBL
      E9Q043

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      7957401..8046158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160769.1XP_036016662.1  fibronectin type III domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      E9Q043
      Conserved Domains (3) summary
      smart00060
      Location:37117
      FN3; Fibronectin type 3 domain
      PHA03247
      Location:5731146
      PHA03247; large tegument protein UL36; Provisional
      cd00063
      Location:15341625
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. XM_006523350.5XP_006523413.1  fibronectin type III domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      E9Q043
      Conserved Domains (3) summary
      smart00060
      Location:37117
      FN3; Fibronectin type 3 domain
      PHA03247
      Location:6131186
      PHA03247; large tegument protein UL36; Provisional
      cd00063
      Location:336426
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RNA

    1. XR_385179.5 RNA Sequence