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    Cntn4 contactin 4 [ Mus musculus (house mouse) ]

    Gene ID: 269784, updated on 3-Dec-2024

    Summary

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    Official Symbol
    Cntn4provided by MGI
    Official Full Name
    contactin 4provided by MGI
    Primary source
    MGI:MGI:1095737
    See related
    Ensembl:ENSMUSG00000064293 AllianceGenome:MGI:1095737
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Axcam; BIG-2; 9630050B05
    Summary
    Predicted to be involved in brain development; negative regulation of neuron differentiation; and neuron projection development. Predicted to be located in extracellular region; plasma membrane; and side of membrane. Is expressed in central nervous system; dorsal root ganglion; and retina. Orthologous to human CNTN4 (contactin 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 2.4), cortex adult (RPKM 2.4) and 6 other tissues See more
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    Genomic context

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    See Cntn4 in Genome Data Viewer
    Location:
    6 E1; 6 48.93 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (105654505..106677102)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (105677632..106700141)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16929 Neighboring gene STARR-seq mESC enhancer starr_16930 Neighboring gene predicted gene, 19757 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene Neighboring gene predicted gene 15631 Neighboring gene STARR-seq mESC enhancer starr_16931 Neighboring gene STARR-seq mESC enhancer starr_16932 Neighboring gene STARR-seq mESC enhancer starr_16934 Neighboring gene STARR-seq mESC enhancer starr_16935 Neighboring gene STARR-seq mESC enhancer starr_16936 Neighboring gene STARR-positive B cell enhancer ABC_E6462 Neighboring gene STARR-positive B cell enhancer ABC_E4850 Neighboring gene STARR-positive B cell enhancer ABC_E9278 Neighboring gene STARR-seq mESC enhancer starr_16937 Neighboring gene STARR-positive B cell enhancer ABC_E3665 Neighboring gene interleukin 5 receptor, alpha Neighboring gene tRNA nucleotidyl transferase, CCA-adding, 1 Neighboring gene cereblon

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional organization of the promoter region of the mouse F3 axonal glycoprotein gene. Cangiano G, et al. Brain Res Mol Brain Res, 1997 Sep. PMID 9332725
    2. The autism risk gene CNTN4 modulates dendritic spine formation. Zhao R, et al. Hum Mol Genet, 2021 Dec 27. PMID 34415325
    3. Cntn4, a risk gene for neuropsychiatric disorders, modulates hippocampal synaptic plasticity and behavior. Oguro-Ando A, et al. Transl Psychiatry, 2021 Feb 4. PMID 33542194, Free PMC Article
    4. Limited impact of Cntn4 mutation on autism-related traits in developing and adult C57BL/6J mice. Molenhuis RT, et al. J Neurodev Disord, 2016. PMID 26958094, Free PMC Article
    5. BIG-2 mediates olfactory axon convergence to target glomeruli. Kaneko-Goto T, et al. Neuron, 2008 Mar 27. PMID 18367085

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CNTN4 modulates neural elongation through interplay with APP.
      Title: CNTN4 modulates neural elongation through interplay with APP.
    2. Protein-tyrosine phosphatase receptor type G (RPTPgamma/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the wiring of the nervous system
      Title: Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.
    3. including the adhesion molecule CNTN4,which contributed to the enhanced response
      Title: Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression.
    4. These results suggest that BIG-2 is one of the axon guidance molecules crucial for the formation and maintenance of functional odor map in the olfactory bulb.
      Title: BIG-2 mediates olfactory axon convergence to target glomeruli.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    contactin-4
    Names
    axonal-associated cell adhesion molecule
    brain-derived immunoglobulin superfamily molecule
    brain-derived immunoglobulin superfamily protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109749.2 → NP_001103219.1  contactin-4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001103219.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 4, and 6-9 all encode the same isoform (1).
      Source sequence(s)
      AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169
      Consensus CDS
      CCDS51866.1
      UniProtKB/Swiss-Prot
      Q14BL8, Q69Z26, Q8BRT6, Q8CBD3
      Related
      ENSMUSP00000108889.3, ENSMUST00000113264.9
      Conserved Domains (3) summary
      cd05853
      Location:513 → 597
      Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
      cd00063
      Location:597 → 690
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:225 → 313
      Ig; Immunoglobulin domain

    2. NM_001109751.2 → NP_001103221.1  contactin-4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001103221.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), also known as BIG-2A, uses alternate 5' and 3' exons, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC153988, AC153991, AC156281, AC159546, AC164169
      Consensus CDS
      CCDS20395.1
      UniProtKB/TrEMBL
      F8WH58
      Conserved Domains (4) summary
      cd00063
      Location:597 → 690
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:27 → 31
      Ig; Ig strand A [structural motif]
      cd05853
      Location:496 → 597
      Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
      cl11960
      Location:25 → 120
      Ig; Immunoglobulin domain

    3. NM_001364565.2 → NP_001351494.1  contactin-4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153988, AC153991, AC156281, AC159546, AC164169
      Consensus CDS
      CCDS51866.1
      UniProtKB/Swiss-Prot
      Q14BL8, Q69Z26, Q8BRT6, Q8CBD3
      Conserved Domains (3) summary
      cd05853
      Location:513 → 597
      Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
      cd00063
      Location:597 → 690
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:225 → 313
      Ig; Immunoglobulin domain

    4. NM_001364566.2 → NP_001351495.1  contactin-4 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169
      Conserved Domains (3) summary
      cd00063
      Location:596 → 689
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:496 → 502
      Ig; Ig strand A [structural motif]
      cl11960
      Location:496 → 596
      Ig; Immunoglobulin domain

    5. NM_001411717.1 → NP_001398646.1  contactin-4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153988, AC153991, AC156281, AC159546, AC164169
      UniProtKB/Swiss-Prot
      Q14BL8, Q69Z26, Q8BRT6, Q8CBD3

    6. NM_001411718.1 → NP_001398647.1  contactin-4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169
      UniProtKB/Swiss-Prot
      Q14BL8, Q69Z26, Q8BRT6, Q8CBD3
      Related
      ENSMUSP00000086616.3, ENSMUST00000089208.9

    7. NM_001411719.1 → NP_001398648.1  contactin-4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153988, AC153991, AC156281, AC159546, AC164169
      UniProtKB/Swiss-Prot
      Q14BL8, Q69Z26, Q8BRT6, Q8CBD3

    8. NM_001411720.1 → NP_001398649.1  contactin-4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153988, AC153991, AC156281, AC159546, AC164169
      UniProtKB/Swiss-Prot
      Q14BL8, Q69Z26, Q8BRT6, Q8CBD3

    9. NM_001411721.1 → NP_001398650.1  contactin-4 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153988, AC153991, AC156281, AC159546, AC164169

    10. NM_001411722.1 → NP_001398651.1  contactin-4 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153988, AC153991, AC156281, AC159546, AC164169

    11. NM_001411723.1 → NP_001398652.1  contactin-4 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169

    12. NM_001411724.1 → NP_001398653.1  contactin-4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169

    13. NM_001411725.1 → NP_001398654.1  contactin-4 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153988, AC153991, AC156281, AC159546, AC164169

    14. NM_001411726.1 → NP_001398655.1  contactin-4 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153988, AC153991, AC156281, AC159546, AC164169

    15. NM_001411727.1 → NP_001398656.1  contactin-4 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169

    16. NM_001411728.1 → NP_001398657.1  contactin-4 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169

    17. NM_001411729.1 → NP_001398658.1  contactin-4 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153988, AC153991, AC156281, AC159546, AC164169

    18. NM_001411730.1 → NP_001398659.1  contactin-4 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153988, AC153991, AC156281, AC159546, AC164169

    19. NM_001411731.1 → NP_001398660.1  contactin-4 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169

    20. NM_001411732.1 → NP_001398661.1  contactin-4 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169

    21. NM_001411733.1 → NP_001398662.1  contactin-4 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153988, AC153991, AC156281, AC159546, AC164169
      UniProtKB/TrEMBL
      F8WH58

    22. NM_001411734.1 → NP_001398663.1  contactin-4 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153988, AC153991, AC156281, AC159546, AC164169
      UniProtKB/TrEMBL
      F8WH58
      Related
      ENSMUSP00000108885.2, ENSMUST00000113260.8

    23. NM_001411735.1 → NP_001398664.1  contactin-4 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169
      UniProtKB/TrEMBL
      F8WH58

    24. NM_001411736.1 → NP_001398665.1  contactin-4 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169
      UniProtKB/TrEMBL
      F8WH58

    25. NM_173004.4 → NP_766592.2  contactin-4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_766592.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' exon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter and distinct C-terminus compared to isoform 1. Variants 2, 3, 22, and 23 all encode the same isoform (2).
      Source sequence(s)
      AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169
      Consensus CDS
      CCDS20395.1
      UniProtKB/TrEMBL
      F8WH58
      Related
      ENSMUSP00000108886.3, ENSMUST00000113261.9
      Conserved Domains (4) summary
      cd00063
      Location:597 → 690
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:27 → 31
      Ig; Ig strand A [structural motif]
      cd05853
      Location:496 → 597
      Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
      cl11960
      Location:25 → 120
      Ig; Immunoglobulin domain

    RNA

    1. NR_177642.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169

    2. NR_177643.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169

    3. NR_177644.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153596, AC153898, AC153988, AC153991, AC156281, AC159546, AC162466, AC164169

    4. NR_177645.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153988, AC153991, AC156281, AC159546, AC164169

    5. NR_177646.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153988, AC153991, AC156281, AC159546, AC164169

    6. NR_177647.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153988, AC153991, AC156281, AC159546, AC164169

    7. NR_177648.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153988, AC153991, AC156281, AC159546, AC164169

    8. NR_177649.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153988, AC153991, AC156281, AC159546, AC164169

    9. NR_177650.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153988, AC153991, AC156281, AC159546, AC164169

    10. NR_177651.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153988, AC153991, AC156281, AC159546, AC164169

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      105654505..106677102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166177.1 → XP_036022070.1  contactin-4 isoform X5

      UniProtKB/TrEMBL
      F8WH58
      Conserved Domains (4) summary
      cd00063
      Location:597 → 690
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:27 → 31
      Ig; Ig strand A [structural motif]
      cd05853
      Location:496 → 597
      Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
      cl11960
      Location:25 → 120
      Ig; Immunoglobulin domain

    2. XM_036166179.1 → XP_036022072.1  contactin-4 isoform X6

      UniProtKB/TrEMBL
      F8WH58
      Conserved Domains (3) summary
      cd00063
      Location:596 → 689
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:496 → 502
      Ig; Ig strand A [structural motif]
      cl11960
      Location:496 → 596
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69Z26.2 GenPept UniProtKB/Swiss-Prot:Q69Z26

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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