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    Grik1 glutamate receptor, ionotropic, kainate 1 [ Mus musculus (house mouse) ]

    Gene ID: 14805, updated on 3-Dec-2024

    Summary

    Official Symbol
    Grik1provided by MGI
    Official Full Name
    glutamate receptor, ionotropic, kainate 1provided by MGI
    Primary source
    MGI:MGI:95814
    See related
    Ensembl:ENSMUSG00000022935 AllianceGenome:MGI:95814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GluK1; GluK5; Glur5; Glur-5; D16Ium24; D16Ium24e; Glurbeta1; A830007B11Rik
    Summary
    Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in CNS E18 (RPKM 5.8), whole brain E14.5 (RPKM 2.9) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Grik1 in Genome Data Viewer
    Location:
    16 C3.3; 16 50.23 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (87692789..88087751, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (87895901..88290863, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32925 Neighboring gene predicted gene, 23994 Neighboring gene RIKEN cDNA 2810407A14 gene Neighboring gene RIKEN cDNA 4930590A17 gene Neighboring gene predicted gene, 51405 Neighboring gene predicted gene, 33207 Neighboring gene predicted gene, 46553 Neighboring gene predicted gene, 41486 Neighboring gene STARR-seq mESC enhancer starr_41409 Neighboring gene STARR-seq mESC enhancer starr_41410 Neighboring gene RIKEN cDNA 4930420G21 gene Neighboring gene predicted gene, 33255 Neighboring gene STARR-seq mESC enhancer starr_41413 Neighboring gene predicted gene, 46546

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (7)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC25101

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-glutamate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables SNARE binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables extracellularly glutamate-gated ion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutamate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutamate-gated calcium ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables glutamate-gated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to heterocyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kainate selective glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables kainate selective glutamate receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kainate selective glutamate receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables kainate selective glutamate receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables kainate selective glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kainate selective glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in L-glutamate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within adult behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within behavioral response to pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within excitatory postsynaptic potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of gamma-aminobutyric acid secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inhibitory postsynaptic potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within inhibitory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ionotropic glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ionotropic glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in modulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of synaptic transmission, glutamatergic IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gamma-aminobutyric acid secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of synaptic transmission, GABAergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within presynaptic modulation of chemical synaptic transmission IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of long-term neuronal synaptic plasticity TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of short-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of short-term neuronal synaptic plasticity TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of synaptic transmission, GABAergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within synaptic transmission, glutamatergic IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ionotropic glutamate receptor complex IC
    Inferred by Curator
    more info
    PubMed 
    part_of ionotropic glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of kainate selective glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of kainate selective glutamate receptor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutamate receptor ionotropic, kainate 1
    Names
    glutamate receptor subunit 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346964.2NP_001333893.2  glutamate receptor ionotropic, kainate 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' exon structure, resulting in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform c, which has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC093479, AC118681, CT030723
      Consensus CDS
      CCDS84256.1
      UniProtKB/TrEMBL
      A0A1B0GSI4, A0A2I3BRJ1
      Related
      ENSMUSP00000147948.2, ENSMUST00000211444.2
      Conserved Domains (2) summary
      cd06382
      Location:38416
      PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
      cl21456
      Location:431800
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    2. NM_001405028.1NP_001391957.1  glutamate receptor ionotropic, kainate 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC093479, AC118681, CT030723
      UniProtKB/TrEMBL
      A0A2I3BPT2, Q8BRT2
      Related
      ENSMUSP00000153786.2, ENSMUST00000227986.2
    3. NM_001405029.1NP_001391958.1  glutamate receptor ionotropic, kainate 1 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC093479, AC118681, CT030723
      UniProtKB/TrEMBL
      A0A2I3BQM2, Q3UZT1
      Related
      ENSMUSP00000154130.2, ENSMUST00000228188.2
    4. NM_001405030.1NP_001391959.1  glutamate receptor ionotropic, kainate 1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC093479, AC118681, CT030723
      UniProtKB/TrEMBL
      A0A2I3BRJ1
      Related
      ENSMUSP00000154596.2, ENSMUST00000228034.2
    5. NM_001405031.1NP_001391960.1  glutamate receptor ionotropic, kainate 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC093479, AC118681, CT030723
      UniProtKB/TrEMBL
      A0A2I3BRJ1
    6. NM_001405032.1NP_001391961.1  glutamate receptor ionotropic, kainate 1 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC093479, AC118681, CT030723
      UniProtKB/TrEMBL
      Q3UZT1
    7. NM_001405033.1NP_001391962.1  glutamate receptor ionotropic, kainate 1 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC093479, AC118681, CT030723
      UniProtKB/TrEMBL
      E9Q2Y1
    8. NM_001405034.1NP_001391963.1  glutamate receptor ionotropic, kainate 1 isoform j

      Status: REVIEWED

      Source sequence(s)
      AC093479, AC118681, CT030723
    9. NM_001405035.1NP_001391964.1  glutamate receptor ionotropic, kainate 1 isoform k precursor

      Status: REVIEWED

      Source sequence(s)
      AC093479, AC118681, CT030723
      UniProtKB/TrEMBL
      Q8BQZ0, Q8C825
    10. NM_010348.4NP_034478.2  glutamate receptor ionotropic, kainate 1 isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is missing an in-frame coding exon at the 3' end compared to transcript variant 1, resulting in a shorter isoform (b) lacking a 29 aa segment compared to isoform a.
      Source sequence(s)
      AC093479, AC118681, CT030723
      Consensus CDS
      CCDS84254.1
      UniProtKB/TrEMBL
      F6Z3M4, Q3UZT1
      Related
      ENSMUSP00000023652.10, ENSMUST00000023652.16
      Conserved Domains (2) summary
      cd06382
      Location:38416
      PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
      cl21456
      Location:431800
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    11. NM_146072.5NP_666184.3  glutamate receptor ionotropic, kainate 1 isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AC093479, AC118681, CT030723
      Consensus CDS
      CCDS84255.1
      UniProtKB/TrEMBL
      F6QF13, Q8BRT2
      Related
      ENSMUSP00000072107.7, ENSMUST00000072256.13
      Conserved Domains (2) summary
      cd06382
      Location:38416
      PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
      cl21456
      Location:431800
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      87692789..88087751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522919.5XP_006522982.1  glutamate receptor ionotropic, kainate 1 isoform X5

      UniProtKB/TrEMBL
      Q8BRT2
      Conserved Domains (2) summary
      cl10011
      Location:40289
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
      cl21456
      Location:304673
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    2. XM_036159782.1XP_036015675.1  glutamate receptor ionotropic, kainate 1 isoform X6

      UniProtKB/TrEMBL
      Q8BRT2
      Conserved Domains (2) summary
      cl10011
      Location:40274
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
      cl21456
      Location:289658
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    3. XM_006522920.4XP_006522983.1  glutamate receptor ionotropic, kainate 1 isoform X9

      UniProtKB/TrEMBL
      Q8BQZ0
      Related
      ENSMUST00000210910.2
      Conserved Domains (2) summary
      cd06382
      Location:38431
      PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
      cl21456
      Location:446600
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    RNA

    1. XR_384929.4 RNA Sequence

    2. XR_384930.5 RNA Sequence