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    Lrrtm3 leucine rich repeat transmembrane neuronal 3 [ Mus musculus (house mouse) ]

    Gene ID: 216028, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lrrtm3provided by MGI
    Official Full Name
    leucine rich repeat transmembrane neuronal 3provided by MGI
    Primary source
    MGI:MGI:2389177
    See related
    Ensembl:ENSMUSG00000042846 AllianceGenome:MGI:2389177
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9630044H04Rik
    Summary
    Acts upstream of or within positive regulation of amyloid-beta formation and positive regulation of synapse assembly. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; future brain; and male reproductive gland or organ. Orthologous to human LRRTM3 (leucine rich repeat transmembrane neuronal 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 10.4), cortex adult (RPKM 6.0) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lrrtm3 in Genome Data Viewer
    Location:
    10 B4; 10 32.57 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (63764276..63926034, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (63928497..64090255, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1121 Neighboring gene STARR-positive B cell enhancer ABC_E2940 Neighboring gene nuclear encoded tRNA serine 3 (anticodon TGA) Neighboring gene catenin alpha 3 Neighboring gene STARR-seq mESC enhancer starr_26935 Neighboring gene STARR-seq mESC enhancer starr_26936 Neighboring gene predicted gene, 30644 Neighboring gene STARR-seq mESC enhancer starr_26937 Neighboring gene STARR-seq mESC enhancer starr_26939 Neighboring gene STARR-seq mESC enhancer starr_26940 Neighboring gene STARR-seq mESC enhancer starr_26941 Neighboring gene STARR-seq mESC enhancer starr_26942 Neighboring gene STARR-seq mESC enhancer starr_26944 Neighboring gene STARR-seq mESC enhancer starr_26945 Neighboring gene STARR-seq mESC enhancer starr_26947 Neighboring gene STARR-seq mESC enhancer starr_26948 Neighboring gene STARR-seq mESC enhancer starr_26949 Neighboring gene predicted gene, 51834 Neighboring gene predicted gene 28881

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density membrane IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in postsynaptic density membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    leucine-rich repeat transmembrane neuronal protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178678.4NP_848793.1  leucine-rich repeat transmembrane neuronal protein 3 precursor

      See identical proteins and their annotated locations for NP_848793.1

      Status: PROVISIONAL

      Source sequence(s)
      AC116138, AC158604
      Consensus CDS
      CCDS35925.1
      UniProtKB/Swiss-Prot
      Q14CH3, Q3TQA3, Q8BGJ7, Q8BZ81
      UniProtKB/TrEMBL
      Q8BZA0
      Related
      ENSMUSP00000101079.2, ENSMUST00000105439.2
      Conserved Domains (4) summary
      smart00013
      Location:3361
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:81300
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:6686
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:133193
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      63764276..63926034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)