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    Ctrb1 chymotrypsinogen B1 [ Mus musculus (house mouse) ]

    Gene ID: 66473, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ctrb1provided by MGI
    Official Full Name
    chymotrypsinogen B1provided by MGI
    Primary source
    MGI:MGI:88559
    See related
    Ensembl:ENSMUSG00000031957 AllianceGenome:MGI:88559
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ctrb; Prt-2; 2200008D09Rik
    Summary
    Enables serine-type endopeptidase activity. Acts upstream of or within proteolysis. Predicted to be located in extracellular region. Is expressed in ovary; pancreas; pancreas tip epithelium; and testis. Orthologous to human CTRB1 (chymotrypsinogen B1) and CTRB2 (chymotrypsinogen B2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in small intestine adult (RPKM 13295.7), spleen adult (RPKM 12146.0) and 2 other tissues See more
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    Genomic context

    See Ctrb1 in Genome Data Viewer
    Location:
    8 E1; 8 57.98 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (112413142..112417642, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111686510..111691010, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene zinc and ring finger 1 Neighboring gene STARR-positive B cell enhancer ABC_E9323 Neighboring gene STARR-positive B cell enhancer ABC_E885 Neighboring gene STARR-positive B cell enhancer ABC_E5042 Neighboring gene STARR-seq mESC enhancer starr_22707 Neighboring gene lactate dehydrogenase D Neighboring gene STARR-seq mESC enhancer starr_22708 Neighboring gene zinc finger protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10523 Neighboring gene microRNA 7076 Neighboring gene VISTA enhancer mm1686 Neighboring gene breast cancer anti-estrogen resistance 1 Neighboring gene STARR-seq mESC enhancer starr_22714 Neighboring gene predicted gene, 51589 Neighboring gene predicted gene, 39252

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Gene trapped (1) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in digestion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to cytokine ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    chymotrypsinogen B
    NP_079859.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025583.2NP_079859.2  chymotrypsinogen B precursor

      See identical proteins and their annotated locations for NP_079859.2

      Status: VALIDATED

      Source sequence(s)
      AC122364, AK007815
      Consensus CDS
      CCDS22679.1
      UniProtKB/Swiss-Prot
      Q9CR35, Q9D8X8, Q9DC86
      Related
      ENSMUSP00000034435.6, ENSMUST00000034435.7
      Conserved Domains (2) summary
      smart00020
      Location:33256
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:34259
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      112413142..112417642 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)