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    Mrm2 mitochondrial rRNA methyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 68017, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mrm2provided by MGI
    Official Full Name
    mitochondrial rRNA methyltransferase 2provided by MGI
    Primary source
    MGI:MGI:1915267
    See related
    Ensembl:ENSMUSG00000029557 AllianceGenome:MGI:1915267
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ftsj2; 2310037B18Rik
    Summary
    Predicted to enable rRNA (uridine-2'-O-)-methyltransferase activity. Predicted to be involved in RNA methylation and mitochondrial large ribosomal subunit assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 17. Orthologous to human MRM2 (mitochondrial rRNA methyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.8), kidney adult (RPKM 5.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mrm2 in Genome Data Viewer
    Location:
    5 G2; 5 78.94 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (140313429..140317653, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (140327674..140331898, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat and fibronectin type III, extracellular 1 Neighboring gene MAD1 mitotic arrest deficient 1-like 1 Neighboring gene predicted gene, 30492 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140619500-140619609 Neighboring gene STARR-seq mESC enhancer starr_14706 Neighboring gene STARR-seq mESC enhancer starr_14707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140684659-140684995 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140686457-140686707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140691391-140691751 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140736675-140736858 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140740159-140740368 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140747294-140747554 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140758495-140758709 Neighboring gene STARR-positive B cell enhancer ABC_E6391 Neighboring gene STARR-seq mESC enhancer starr_14708 Neighboring gene nudix hydrolase 1 Neighboring gene STARR-positive B cell enhancer ABC_E9018 Neighboring gene STARR-positive B cell enhancer ABC_E9267 Neighboring gene sorting nexin 8 Neighboring gene predicted gene, 30550

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables rRNA (uridine-2'-O-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables rRNA (uridine-2'-O-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables rRNA (uridine-2'-O-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in RNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial large ribosomal subunit assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial large ribosomal subunit assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rRNA methylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in rRNA processing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    rRNA methyltransferase 2, mitochondrial
    Names
    16S rRNA (uridine(1369)-2'-O)-methyltransferase
    16S rRNA [Um1369] 2'-O-methyltransferase
    FtsJ RNA methyltransferase homolog 2
    FtsJ homolog 2
    protein ftsJ homolog 2
    putative ribosomal RNA methyltransferase 2
    rRNA (uridine-2'-O-)-methyltransferase
    NP_080786.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026510.1NP_080786.1  rRNA methyltransferase 2, mitochondrial

      See identical proteins and their annotated locations for NP_080786.1

      Status: PROVISIONAL

      Source sequence(s)
      AK009656
      Consensus CDS
      CCDS39355.1
      UniProtKB/Swiss-Prot
      Q9CPY0
      Related
      ENSMUSP00000031536.8, ENSMUST00000031536.8
      Conserved Domains (1) summary
      COG0293
      Location:33239
      RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      140313429..140317653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)