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    Il1rapl1 interleukin 1 receptor accessory protein-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 331461, updated on 27-Nov-2024

    Summary

    Official Symbol
    Il1rapl1provided by MGI
    Official Full Name
    interleukin 1 receptor accessory protein-like 1provided by MGI
    Primary source
    MGI:MGI:2687319
    See related
    Ensembl:ENSMUSG00000052372 AllianceGenome:MGI:2687319
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IL1R8; MRX34; OPHN4; IL1RAPL; TIGIRR-2; IL1RAPL-1; C030039N24; 6330532G10Rik
    Summary
    Enables signaling receptor binding activity. Involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; positive regulation of nervous system development; and synapse organization. Located in cell surface and dendrite. Is expressed in central nervous system; dorsal root ganglion; eye; lung; and trigeminal nerve. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 21. Orthologous to human IL1RAPL1 (interleukin 1 receptor accessory protein like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 1.3), cortex adult (RPKM 1.1) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Il1rapl1 in Genome Data Viewer
    Location:
    X C1; X 39.89 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (85784543..87159554, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (86740937..88115948, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene MAGE family member B7, pseudogene Neighboring gene STARR-seq mESC enhancer starr_47501 Neighboring gene STARR-seq mESC enhancer starr_47502 Neighboring gene predicted gene, 39524 Neighboring gene STARR-seq mESC enhancer starr_47503 Neighboring gene family with sequence similarity 48, member A pseudogene Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47504 Neighboring gene prohibitin pseudogene Neighboring gene nucleophosmin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47505 Neighboring gene predicted gene 14774 Neighboring gene predicted gene, 25006 Neighboring gene STARR-seq mESC enhancer starr_47507 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables interleukin-1 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in presynaptic membrane assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of postsynapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic membrane adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in trans-synaptic signaling by trans-synaptic complex ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    interleukin-1 receptor accessory protein-like 1
    Names
    X-linked interleukin-1 receptor accessory protein-like 1
    NP_001153875.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160403.2NP_001153875.1  interleukin-1 receptor accessory protein-like 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL627409, AL672059, AL844869, AL844900, AL954362, BX005231
      Consensus CDS
      CCDS53128.1
      UniProtKB/Swiss-Prot
      P59823
      UniProtKB/TrEMBL
      B1ASU0
      Related
      ENSMUSP00000109599.2, ENSMUST00000113966.8
      Conserved Domains (5) summary
      cd05896
      Location:32135
      Ig1_IL1RAPL-1_like; First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1)
      PHA02785
      Location:9334
      PHA02785; IL-beta-binding protein; Provisional
      smart00408
      Location:260341
      IGc2; Immunoglobulin C-2 Type
      pfam01582
      Location:405559
      TIR; TIR domain
      cl11960
      Location:148234
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      85784543..87159554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)