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    Ubash3a ubiquitin associated and SH3 domain containing, A [ Mus musculus (house mouse) ]

    Gene ID: 328795, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ubash3aprovided by MGI
    Official Full Name
    ubiquitin associated and SH3 domain containing, Aprovided by MGI
    Primary source
    MGI:MGI:1926074
    See related
    Ensembl:ENSMUSG00000042345 AllianceGenome:MGI:1926074
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TULA; Sts-2; TULA-1; C330001M22; 5830413C03Rik
    Summary
    Acts upstream of or within negative regulation of T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in cytosol and nuclear speck. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skin. Orthologous to human UBASH3A (ubiquitin associated and SH3 domain containing A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 15.3), liver E14.5 (RPKM 3.3) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ubash3a in Genome Data Viewer
    Location:
    17 A3.3- B1; 17 15.84 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (31426842..31478655)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (31207868..31259681)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15318 Neighboring gene trefoil factor 1 Neighboring gene transmembrane protease, serine 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31341993-31342102 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31344766-31345042 Neighboring gene STARR-positive B cell enhancer ABC_E3196 Neighboring gene STARR-positive B cell enhancer ABC_E10945 Neighboring gene radial spoke head 1 homolog (Chlamydomonas) Neighboring gene STARR-seq mESC enhancer starr_42328 Neighboring gene solute carrier family 37 (glycerol-3-phosphate transporter), member 1 Neighboring gene predicted gene, 30139 Neighboring gene STARR-seq mESC enhancer starr_42332 Neighboring gene phosphodiesterase 9A Neighboring gene STARR-seq mESC enhancer starr_42334 Neighboring gene predicted gene 9902

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin-associated and SH3 domain-containing protein A
    Names
    T-cell ubiquitin ligand 1
    suppressor of T-cell receptor signaling 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177823.4NP_808491.2  ubiquitin-associated and SH3 domain-containing protein A

      See identical proteins and their annotated locations for NP_808491.2

      Status: VALIDATED

      Source sequence(s)
      AK040572, BB736706, BC027561, BY227020
      Consensus CDS
      CCDS50054.1
      UniProtKB/Swiss-Prot
      Q3TED7, Q3V3E1
      Related
      ENSMUSP00000158544.2, ENSMUST00000236745.2
      Conserved Domains (4) summary
      cd07040
      Location:361456
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
      cd11937
      Location:241300
      SH3_UBASH3A; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein A
      cd14300
      Location:2561
      UBA_UBS3A_like; UBA domain found in ubiquitin-associated and SH3 domain-containing protein A (UBS3A) and similar proteins
      pfam00300
      Location:413575
      His_Phos_1; Histidine phosphatase superfamily (branch 1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      31426842..31478655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524434.5XP_006524497.1  ubiquitin-associated and SH3 domain-containing protein A isoform X1

      UniProtKB/TrEMBL
      A0A498WGR9
      Related
      ENSMUSP00000045890.9, ENSMUST00000048656.15
      Conserved Domains (3) summary
      cd07067
      Location:361476
      HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
      cd11937
      Location:241300
      SH3_UBASH3A; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein A
      cd14300
      Location:2561
      UBA_UBS3A_like; UBA domain found in ubiquitin-associated and SH3 domain-containing protein A (UBS3A) and similar proteins

    RNA

    1. XR_003952136.2 RNA Sequence

    2. XR_876514.4 RNA Sequence

    3. XR_876515.4 RNA Sequence