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    Hnrnpc heterogeneous nuclear ribonucleoprotein C [ Mus musculus (house mouse) ]

    Gene ID: 15381, updated on 3-Dec-2024

    Summary

    Official Symbol
    Hnrnpcprovided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Cprovided by MGI
    Primary source
    MGI:MGI:107795
    See related
    Ensembl:ENSMUSG00000060373 AllianceGenome:MGI:107795
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hnrpc; Hnrpc1; Hnrpc2; hnRNPC1; hnRNPC2; hnrnp-C; D14Wsu171e
    Summary
    Enables mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and negative regulation of nucleobase-containing compound metabolic process. Located in pronucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human HNRNPC (heterogeneous nuclear ribonucleoprotein C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 123.0), CNS E14 (RPKM 61.1) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Hnrnpc in Genome Data Viewer
    Location:
    14 C2; 14 26.79 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52310834..52341462, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (52073377..52104039, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22354 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene retinitis pigmentosa GTPase regulator interacting protein 1 Neighboring gene MRT4, mRNA turnover 4, homolog pseudogene Neighboring gene SPT16, facilitates chromatin remodeling subunit Neighboring gene STARR-positive B cell enhancer ABC_E7310 Neighboring gene STARR-seq mESC enhancer starr_36700

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (2)  1 citation
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N6-methyladenosine-containing RNA reader activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables N6-methyladenosine-containing RNA reader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables deaminase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables telomerase RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of mRNA modification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasmic periphery of the nuclear pore complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoproteins C1/C2
    Names
    heterogeneous nuclear ribonucleoprotein C1
    heterogeneous nuclear ribonucleoprotein C2
    heterogeneous ribonucleoprotein C1/C2
    hnRNP C1 / hnRNP C2
    hnRNP C1/C2
    hnRNP C2
    snoRNA MBI-122

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170981.3NP_001164452.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 2

      See identical proteins and their annotated locations for NP_001164452.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2, 3 and 13 encode the same isoform (2).
      Source sequence(s)
      AC157572
      Consensus CDS
      CCDS88662.1
      UniProtKB/TrEMBL
      Q3U6P5
      Related
      ENSMUSP00000154757.2, ENSMUST00000227242.2
      Conserved Domains (1) summary
      cd12603
      Location:1093
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    2. NM_001170982.3NP_001164453.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 2

      See identical proteins and their annotated locations for NP_001164453.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR and uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2, 3 and 13 encode the same isoform (2).
      Source sequence(s)
      AC157572
      Consensus CDS
      CCDS88662.1
      UniProtKB/TrEMBL
      Q3U6P5
      Related
      ENSMUSP00000154737.2, ENSMUST00000227536.2
      Conserved Domains (1) summary
      cd12603
      Location:1093
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    3. NM_001170983.3NP_001164454.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 3

      See identical proteins and their annotated locations for NP_001164454.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1. Variants 4, 14, 15 and 16 encode the same isoform (3).
      Source sequence(s)
      AC157572
      Consensus CDS
      CCDS88661.1
      UniProtKB/Swiss-Prot
      Q9Z204
      Related
      ENSMUSP00000154166.2, ENSMUST00000228748.2
      Conserved Domains (1) summary
      cd12603
      Location:1093
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    4. NM_001170984.3NP_001164455.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 4

      See identical proteins and their annotated locations for NP_001164455.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1. Variants 5, 17 and 18 encode the same isoform (4).
      Source sequence(s)
      AC157572
      Consensus CDS
      CCDS88660.1
      UniProtKB/TrEMBL
      Q3U6P5
      Related
      ENSMUSP00000154238.2, ENSMUST00000227458.2
      Conserved Domains (1) summary
      cd12603
      Location:1093
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    5. NM_001360172.2NP_001347101.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157572
      Consensus CDS
      CCDS36917.1
      UniProtKB/Swiss-Prot
      Q3TLB5, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83, Q9Z204
      UniProtKB/TrEMBL
      Q3U6P5
      Conserved Domains (1) summary
      cd12603
      Location:1093
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    6. NM_001360173.2NP_001347102.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157572
      Consensus CDS
      CCDS36917.1
      UniProtKB/Swiss-Prot
      Q3TLB5, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83, Q9Z204
      UniProtKB/TrEMBL
      Q3U6P5
      Conserved Domains (1) summary
      cd12603
      Location:1093
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    7. NM_001360174.2NP_001347103.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC157572
      Consensus CDS
      CCDS88659.1
      Related
      ENSMUSP00000154212.2, ENSMUST00000228198.2
      Conserved Domains (1) summary
      cd12603
      Location:1093
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    8. NM_001360175.2NP_001347104.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC157572
      Consensus CDS
      CCDS88659.1
      Conserved Domains (1) summary
      cd12603
      Location:1093
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    9. NM_001360176.2NP_001347105.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC157572
      UniProtKB/TrEMBL
      Q3U6P5
      Conserved Domains (1) summary
      cd12603
      Location:1093
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    10. NM_001360177.2NP_001347106.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC157572
      UniProtKB/TrEMBL
      Q3U6P5
      Conserved Domains (1) summary
      cd12603
      Location:1093
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    11. NM_001360178.2NP_001347107.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC157572
      UniProtKB/TrEMBL
      Q3U6P5
      Conserved Domains (1) summary
      cd12603
      Location:1093
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    12. NM_001360179.2NP_001347108.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157572
      Consensus CDS
      CCDS88662.1
      UniProtKB/TrEMBL
      Q3U6P5
      Conserved Domains (1) summary
      cd12603
      Location:1093
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    13. NM_001360180.2NP_001347109.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157572
      Consensus CDS
      CCDS88661.1
      Conserved Domains (1) summary
      cd12603
      Location:1093
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    14. NM_001360181.2NP_001347110.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157572
      Consensus CDS
      CCDS88661.1
      Conserved Domains (1) summary
      cd12603
      Location:1093
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    15. NM_001360182.2NP_001347111.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157572
      Consensus CDS
      CCDS88661.1
      Related
      ENSMUSP00000154619.2, ENSMUST00000228232.2
      Conserved Domains (1) summary
      cd12603
      Location:1093
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    16. NM_001360183.2NP_001347112.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC157572
      Consensus CDS
      CCDS88660.1
      UniProtKB/TrEMBL
      Q3U6P5
      Conserved Domains (1) summary
      cd12603
      Location:1093
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    17. NM_001360184.2NP_001347113.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC157572
      Consensus CDS
      CCDS88660.1
      UniProtKB/TrEMBL
      Q3U6P5
      Conserved Domains (1) summary
      cd12603
      Location:1093
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)
    18. NM_001424475.1NP_001411404.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC157572
      UniProtKB/TrEMBL
      Q3U6P5
    19. NM_001424476.1NP_001411405.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157572
      UniProtKB/TrEMBL
      Q3U6P5
    20. NM_001424477.1NP_001411406.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC157572
    21. NM_001424478.1NP_001411407.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157572
      UniProtKB/Swiss-Prot
      Q3TLB5, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83, Q9Z204
      UniProtKB/TrEMBL
      Q3U6P5
    22. NM_001424479.1NP_001411408.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC157572
      UniProtKB/TrEMBL
      Q3U6P5
    23. NM_001424480.1NP_001411409.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157572
      UniProtKB/TrEMBL
      Q3U6P5
    24. NM_001424481.1NP_001411410.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC157572
      UniProtKB/TrEMBL
      Q3U6P5
    25. NM_001424482.1NP_001411411.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC157572
    26. NM_016884.5NP_058580.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform 1

      See identical proteins and their annotated locations for NP_058580.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1). Variants 1, 6 and 7 encode the same isoform (1).
      Source sequence(s)
      AC157572
      Consensus CDS
      CCDS36917.1
      UniProtKB/Swiss-Prot
      Q3TLB5, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83, Q9Z204
      UniProtKB/TrEMBL
      Q3U6P5
      Related
      ENSMUSP00000107237.5, ENSMUST00000111610.12
      Conserved Domains (1) summary
      cd12603
      Location:1093
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      52310834..52341462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158467.1XP_036014360.1  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1

      UniProtKB/Swiss-Prot
      Q3TLB5, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83, Q9Z204
      UniProtKB/TrEMBL
      Q3U6P5
      Conserved Domains (1) summary
      cd12603
      Location:1093
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)