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    Ralgapa1 Ral GTPase activating protein, alpha subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 56784, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ralgapa1provided by MGI
    Official Full Name
    Ral GTPase activating protein, alpha subunit 1provided by MGI
    Primary source
    MGI:MGI:1931050
    See related
    Ensembl:ENSMUSG00000021027 AllianceGenome:MGI:1931050
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GRIPE; Garnl1; Tulip1; mKIAA0884; 2310003F20Rik; 4930400K19Rik
    Summary
    Predicted to enable GTPase activator activity and protein heterodimerization activity. Acts upstream of with a negative effect on negative regulation of DNA-binding transcription factor activity. Located in cytoplasm and nucleus. Is expressed in several structures, including 1st branchial arch; brain; metanephros; placenta; and trunk. Orthologous to human RALGAPA1 (Ral GTPase activating protein catalytic subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 10.1), whole brain E14.5 (RPKM 7.9) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ralgapa1 in Genome Data Viewer
    Location:
    12 C1; 12 24.06 cM
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (55649673..55868522, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (55602888..55821574, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32194 Neighboring gene aldolase 1 A, retrogene 2 Neighboring gene insulinoma-associated 2 Neighboring gene STARR-seq mESC enhancer starr_32196 Neighboring gene STARR-seq mESC enhancer starr_32197 Neighboring gene STARR-positive B cell enhancer ABC_E11776 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:56937027-56937210 Neighboring gene breast cancer metastasis-suppressor 1-like Neighboring gene STARR-seq mESC enhancer starr_32198 Neighboring gene predicted gene, 22296

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables GTPase activator activity ISM
    Inferred from Sequence Model
    more info
    PubMed 
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ral GTPase-activating protein subunit alpha-1
    Names
    GAP-related interacting partner to E12
    GTPase activating RANGAP domain-like 1
    GTPase-activating RapGAP domain-like 1
    p240
    ral GTPase-activating protein alpha subunit 1
    tuberin-like protein 1
    tulip 1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003719.3NP_001003719.1  ral GTPase-activating protein subunit alpha-1 isoform 3

      See identical proteins and their annotated locations for NP_001003719.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region and an internal exon in the 3' region which results in an alternate downstream termination codon, compared to variant 4. The resulting isoform (3) lacks an internal segment but has a longer and distinct C-terminus, compared to isoform 4.
      Source sequence(s)
      AC107633, AC158398, AC159624
      UniProtKB/TrEMBL
      B7ZNA3
      Conserved Domains (1) summary
      pfam02145
      Location:18252001
      Rap_GAP; Rap/ran-GAP
    2. NM_001112714.3NP_001106185.1  ral GTPase-activating protein subunit alpha-1 isoform 2

      See identical proteins and their annotated locations for NP_001106185.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an in-frame exon in the 5' coding region and a 3 nt exon in the 3' UTR, compared to variant 4. The resulting isoform (2) lacks an internal segment, compared to isoform 4. Variants 1 and 2 encode the same isoform 2.
      Source sequence(s)
      AC107633, AC158398, AC159624
      Consensus CDS
      CCDS36452.1
      UniProtKB/Swiss-Prot
      Q6GYP6, Q6GYP7, Q6ZQ28, Q8BNJ5, Q8C9G8, Q8CIW4, Q9JMC4
      UniProtKB/TrEMBL
      B7ZNA3
      Related
      ENSMUSP00000082503.6, ENSMUST00000085385.7
      Conserved Domains (1) summary
      pfam02145
      Location:18252001
      Rap_GAP; Rap/ran-GAP
    3. NM_001286263.2NP_001273192.1  ral GTPase-activating protein subunit alpha-1 isoform 4

      See identical proteins and their annotated locations for NP_001273192.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes isoform 4.
      Source sequence(s)
      AC107633, AC158398, AC159624
      Consensus CDS
      CCDS88339.1
      UniProtKB/TrEMBL
      A0A1W2P832, B7ZNA3
      Conserved Domains (1) summary
      pfam02145
      Location:18722048
      Rap_GAP; Rap/ran-GAP
    4. NM_001368814.2NP_001355743.1  ral GTPase-activating protein subunit alpha-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107633, AC158398, AC159624
      UniProtKB/TrEMBL
      A0A2I3BRX9
      Conserved Domains (1) summary
      pfam02145
      Location:23282504
      Rap_GAP; Rap/ran-GAP
    5. NM_019994.6NP_064378.4  ral GTPase-activating protein subunit alpha-1 isoform 2

      See identical proteins and their annotated locations for NP_064378.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 4. The resulting isoform (2) lacks an internal segment, compared to isoform 4. Variants 1 and 2 encode the same isoform 2.
      Source sequence(s)
      AC107633, AC158398, AC159624
      Consensus CDS
      CCDS36452.1
      UniProtKB/Swiss-Prot
      Q6GYP6, Q6GYP7, Q6ZQ28, Q8BNJ5, Q8C9G8, Q8CIW4, Q9JMC4
      UniProtKB/TrEMBL
      B7ZNA3
      Conserved Domains (1) summary
      pfam02145
      Location:18252001
      Rap_GAP; Rap/ran-GAP

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      55649673..55868522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516109.4XP_006516172.3  ral GTPase-activating protein subunit alpha-1 isoform X3

      UniProtKB/TrEMBL
      A0A2I3BRX9
      Related
      ENSMUSP00000154749.2, ENSMUST00000226244.2
      Conserved Domains (1) summary
      pfam02145
      Location:22812457
      Rap_GAP; Rap/ran-GAP
    2. XM_036157540.1XP_036013433.1  ral GTPase-activating protein subunit alpha-1 isoform X4

      UniProtKB/TrEMBL
      A0A2I3BRX9
      Conserved Domains (1) summary
      pfam02145
      Location:22812457
      Rap_GAP; Rap/ran-GAP
    3. XM_006516104.4XP_006516167.1  ral GTPase-activating protein subunit alpha-1 isoform X5

      UniProtKB/TrEMBL
      B7ZNA3
      Conserved Domains (1) summary
      pfam02145
      Location:18722048
      Rap_GAP; Rap/ran-GAP
    4. XM_036157542.1XP_036013435.1  ral GTPase-activating protein subunit alpha-1 isoform X7

      UniProtKB/TrEMBL
      A0A1W2P832, B7ZNA3
      Related
      ENSMUSP00000151857.2, ENSMUST00000219432.2
      Conserved Domains (1) summary
      pfam02145
      Location:18722048
      Rap_GAP; Rap/ran-GAP
    5. XM_030246826.2XP_030102686.1  ral GTPase-activating protein subunit alpha-1 isoform X2

      UniProtKB/TrEMBL
      A0A2I3BRX9
      Conserved Domains (1) summary
      pfam02145
      Location:23282504
      Rap_GAP; Rap/ran-GAP
    6. XM_030246825.2XP_030102685.1  ral GTPase-activating protein subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A2I3BRX9
      Conserved Domains (1) summary
      pfam02145
      Location:23282504
      Rap_GAP; Rap/ran-GAP
    7. XM_036157544.1XP_036013437.1  ral GTPase-activating protein subunit alpha-1 isoform X10

      Conserved Domains (1) summary
      pfam02145
      Location:11021278
      Rap_GAP; Rap/ran-GAP
    8. XM_036157545.1XP_036013438.1  ral GTPase-activating protein subunit alpha-1 isoform X11

      Conserved Domains (1) summary
      pfam02145
      Location:10961272
      Rap_GAP; Rap/ran-GAP
    9. XM_006516107.4XP_006516170.1  ral GTPase-activating protein subunit alpha-1 isoform X8

      UniProtKB/TrEMBL
      A0A1W2P712, B7ZNA3
      Related
      ENSMUSP00000151498.2, ENSMUST00000220367.2
      Conserved Domains (1) summary
      pfam02145
      Location:18252001
      Rap_GAP; Rap/ran-GAP
    10. XM_036157541.1XP_036013434.1  ral GTPase-activating protein subunit alpha-1 isoform X6

      UniProtKB/TrEMBL
      B7ZNA3
      Conserved Domains (1) summary
      pfam02145
      Location:18722048
      Rap_GAP; Rap/ran-GAP
    11. XM_036157543.1XP_036013436.1  ral GTPase-activating protein subunit alpha-1 isoform X9

    RNA

    1. XR_004937530.1 RNA Sequence

    2. XR_004937531.1 RNA Sequence