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    Nubp2 nucleotide binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 26426, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nubp2provided by MGI
    Official Full Name
    nucleotide binding protein 2provided by MGI
    Primary source
    MGI:MGI:1347072
    See related
    Ensembl:ENSMUSG00000039183 AllianceGenome:MGI:1347072
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D17Wsu11e
    Summary
    Predicted to enable iron-sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly. Located in nucleus and spindle pole centrosome. Is expressed in several structures, including extraembryonic component; genitourinary system; liver; lung; and spleen. Orthologous to human NUBP2 (NUBP iron-sulfur cluster assembly factor 2, cytosolic). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 44.5), thymus adult (RPKM 22.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nubp2 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.53 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25101585..25105423, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24882611..24886350, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene STARR-positive B cell enhancer ABC_E486 Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene predicted gene, 41549 Neighboring gene STARR-seq mESC enhancer starr_42099 Neighboring gene STARR-seq mESC enhancer starr_42100 Neighboring gene insulin-like growth factor binding protein, acid labile subunit Neighboring gene STARR-positive B cell enhancer ABC_E216 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene mitochondrial ribosomal protein S34

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Random monoallelic expression of three genes clustered within 60 kb of mouse t complex genomic DNA. Sano Y, et al. Genome Res, 2001 Nov. PMID 11691847, Free PMC Article
    2. Comparison of intracellular localization of Nubp1 and Nubp2 using GFP fusion proteins. Okuno T, et al. Mol Biol Rep, 2010 Mar. PMID 19263241
    3. A novel family of katanin-like 2 protein isoforms (KATNAL2), interacting with nucleotide-binding proteins Nubp1 and Nubp2, are key regulators of different MT-based processes in mammalian cells. Ververis A, et al. Cell Mol Life Sci, 2016 Jan. PMID 26153462, Free PMC Article
    4. The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis. Kypri E, et al. Cell Mol Life Sci, 2014 Feb. PMID 23807208, Free PMC Article
    5. Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication. Christodoulou A, et al. J Cell Sci, 2006 May 15. PMID 16638812

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nubp2 is required for cranial neural crest survival in the mouse.
      Title: Nubp2 is required for cranial neural crest survival in the mouse.
    2. KATNAL2 isoforms interact with themselves, with each other and with Nubp1 and Nubp2.
      Title: A novel family of katanin-like 2 protein isoforms (KATNAL2), interacting with nucleotide-binding proteins Nubp1 and Nubp2, are key regulators of different MT-based processes in mammalian cells.
    3. The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis.
      Title: The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis.
    4. Both termini of Nubp2 contribute to nuclear transfer of Nubp2 and morphology of the nucleus.
      Title: Comparison of intracellular localization of Nubp1 and Nubp2 using GFP fusion proteins.
    5. KIFC5A interacts with nucleotide-binding proteins 1 and 2 (Nubp1 and Nubp2). Nubp1 and Nubp2 also interact with each other.
      Title: Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent FeS chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytosolic Fe-S cluster assembly factor NUBP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355396.1 → NP_001342325.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166102
      Consensus CDS
      CCDS89014.1
      UniProtKB/TrEMBL
      A0A3Q4EH93
      Conserved Domains (1) summary
      pfam10609
      Location:1 → 203
      ParA; NUBPL iron-transfer P-loop NTPase

    2. NM_001379052.1 → NP_001365981.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC166102
      UniProtKB/TrEMBL
      A0A3Q4L2S1
      Conserved Domains (1) summary
      pfam10609
      Location:12 → 263
      ParA; NUBPL iron-transfer P-loop NTPase

    3. NM_001379053.1 → NP_001365982.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166102
      UniProtKB/TrEMBL
      A0A3Q4EH93
      Conserved Domains (1) summary
      pfam10609
      Location:1 → 203
      ParA; NUBPL iron-transfer P-loop NTPase

    4. NM_001379054.1 → NP_001365983.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166102
      UniProtKB/TrEMBL
      A0A3Q4EH93
      Conserved Domains (1) summary
      pfam10609
      Location:1 → 203
      ParA; NUBPL iron-transfer P-loop NTPase

    5. NM_001379055.1 → NP_001365984.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166102
      UniProtKB/TrEMBL
      A0A3Q4EH93
      Conserved Domains (1) summary
      pfam10609
      Location:1 → 203
      ParA; NUBPL iron-transfer P-loop NTPase

    6. NM_001379056.1 → NP_001365985.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166102
      UniProtKB/TrEMBL
      A0A3Q4EH93
      Related
      ENSMUSP00000157378.2, ENSMUST00000234928.2
      Conserved Domains (1) summary
      pfam10609
      Location:1 → 203
      ParA; NUBPL iron-transfer P-loop NTPase

    7. NM_011956.3 → NP_036086.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 1

      See identical proteins and their annotated locations for NP_036086.1

      Status: VALIDATED

      Source sequence(s)
      AF114169, BI735707, BU700400
      Consensus CDS
      CCDS28500.1
      UniProtKB/Swiss-Prot
      Q9R061
      UniProtKB/TrEMBL
      A0A3Q4L2S1
      Related
      ENSMUSP00000049319.6, ENSMUST00000044252.7
      Conserved Domains (1) summary
      pfam10609
      Location:17 → 266
      ParA; NUBPL iron-transfer P-loop NTPase

    RNA

    1. NR_166441.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166102
      Related
      ENSMUST00000234293.2

    2. NR_166442.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166102
      Related
      ENSMUST00000234261.2

    3. NR_166443.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166102
      Related
      ENSMUST00000234352.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25101585..25105423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160624.1 → XP_036016517.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q4EGU9
      Related
      ENSMUSP00000157175.2, ENSMUST00000234968.2
      Conserved Domains (1) summary
      pfam10609
      Location:44 → 256
      ParA; NUBPL iron-transfer P-loop NTPase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R061.1 GenPept UniProtKB/Swiss-Prot:Q9R061

    Gene LinkOut

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