Myom3 myomesin family, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myom3provided by MGI
Official Full Name: myomesin family, member 3provided by MGI
Primary source: MGI:MGI:2685280
See related: Ensembl:ENSMUSG00000037139 AllianceGenome:MGI:2685280
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm434; 8430427K15Rik
Summary: Enables protein homodimerization activity. Predicted to be involved in sarcomere organization. Located in M band. Is expressed in diaphragm; heart; leg; musculature; and somite. Orthologous to human MYOM3 (myomesin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in limb E14.5 (RPKM 2.0), placenta adult (RPKM 0.8) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 68.0 cM

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (135486688..135542882)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (135758800..135815571)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MYOM3 fragments hold promise for minimally invasive assessment of experimental therapies for DMD and other neuromuscular disorders.
Title: Serum proteomic profiling reveals fragments of MYOM3 as potential biomarkers for monitoring the outcome of therapeutic interventions in muscular dystrophies.
Myomesin 3, a novel structural component of the M-band in striated muscle.
Title: Myomesin 3, a novel structural component of the M-band in striated muscle.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Myom3 (e-PCR), detects polymorphism
- UniSTS:536591

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in M band	IBA Inferred from Biological aspect of Ancestor more info
located_in M band	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: myomesin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085509.2 → NP_001078978.1 myomesin-3

See identical proteins and their annotated locations for NP_001078978.1

Status: VALIDATED

Source sequence(s)

AL662911

Consensus CDS

CCDS38921.1

UniProtKB/Swiss-Prot

A2ABU4

Related

ENSMUSP00000101480.2, ENSMUST00000105854.2

Conserved Domains (5) summary

cd00096
Location:171 → 244

Ig; Immunoglobulin domain

smart00410
Location:1137 → 1207

IG_like; Immunoglobulin like

cd00063
Location:804 → 893

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1343 → 1426

I-set; Immunoglobulin I-set domain

cl11960
Location:1336 → 1426

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

135486688..135542882

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017320223.3 → XP_017175712.1 myomesin-3 isoform X1

Conserved Domains (3) summary

cd00063
Location:804 → 893

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:154 → 247

I-set; Immunoglobulin I-set domain

cl11960
Location:272 → 363

Ig; Immunoglobulin domain
XM_017320224.2 → XP_017175713.1 myomesin-3 isoform X2

Conserved Domains (3) summary

cd00063
Location:221 → 310

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:555 → 619

Ig; Immunoglobulin domain

cl11960
Location:753 → 843

Ig; Immunoglobulin domain