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    Tmem190 transmembrane protein 190 [ Mus musculus (house mouse) ]

    Gene ID: 78052, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem190provided by MGI
    Official Full Name
    transmembrane protein 190provided by MGI
    Primary source
    MGI:MGI:1925302
    See related
    Ensembl:ENSMUSG00000013091 AllianceGenome:MGI:1925302
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930572D21Rik
    Summary
    Enables identical protein binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in inner acrosomal membrane. Orthologous to human TMEM190 (transmembrane protein 190). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 55.9) See more
    Orthologs
    human all
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    Genomic context

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    See Tmem190 in Genome Data Viewer
    Location:
    7 A1; 7 2.77 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4784788..4787340)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4782549..4784341)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17937 Neighboring gene cytochrome c oxidase subunit 6B2 Neighboring gene golgi associated RAB2 interactor family member 5B Neighboring gene interleukin 11 Neighboring gene transmembrane protein 238 Neighboring gene STARR-positive B cell enhancer ABC_E6507 Neighboring gene predicted gene, 57780 Neighboring gene ribosomal protein L28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of mouse sperm TMEM190, a small transmembrane protein with the trefoil domain: evidence for co-localization with IZUMO1 and complex formation with other sperm proteins. Nishimura H, et al. Reproduction, 2011 Apr. PMID 21273369
    2. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A mouse sperm protein complex(es) including TMEM190 plays an indirect role(s) in sperm-oocyte fusion.
      Title: Characterization of mouse sperm TMEM190, a small transmembrane protein with the trefoil domain: evidence for co-localization with IZUMO1 and complex formation with other sperm proteins.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hematopoietic progenitor cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in inner acrosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in inner acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane protein 190

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030028.1 → NP_084304.1  transmembrane protein 190 precursor

      See identical proteins and their annotated locations for NP_084304.1

      Status: VALIDATED

      Source sequence(s)
      AK019807, BU936271, BX631095
      Consensus CDS
      CCDS51976.1
      UniProtKB/Swiss-Prot
      Q9D2E9
      Related
      ENSMUSP00000013235.5, ENSMUST00000013235.6
      Conserved Domains (1) summary
      pfam15431
      Location:22 → 142
      TMEM190; Transmembrane protein 190

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      4784788..4787340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153565.1 → XP_036009458.1  transmembrane protein 190 isoform X2

      Conserved Domains (1) summary
      pfam15431
      Location:29 → 154
      TMEM190; Transmembrane protein 190

    2. XM_006540434.4 → XP_006540497.1  transmembrane protein 190 isoform X1

      Conserved Domains (1) summary
      pfam15431
      Location:42 → 167
      TMEM190; Transmembrane protein 190
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2E9.1 GenPept UniProtKB/Swiss-Prot:Q9D2E9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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