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    Brf2 BRF2, RNA polymerase III transcription initiation factor 50kDa subunit [ Mus musculus (house mouse) ]

    Gene ID: 66653, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Brf2provided by MGI
    Official Full Name
    BRF2, RNA polymerase III transcription initiation factor 50kDa subunitprovided by MGI
    Primary source
    MGI:MGI:1913903
    See related
    Ensembl:ENSMUSG00000031487 AllianceGenome:MGI:1913903
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BRFU; TFIIIB50; 2700059M06Rik; 5730512K07Rik
    Summary
    Predicted to enable RNA polymerase II general transcription initiation factor activity; RNA polymerase III type 3 promoter sequence-specific DNA binding activity; and TBP-class protein binding activity. Predicted to be involved in cellular response to oxidative stress and regulation of transcription by RNA polymerase III. Predicted to be part of transcription factor TFIIIB complex and transcription preinitiation complex. Predicted to be active in nucleus. Orthologous to human BRF2 (BRF2 general transcription factor IIIB subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 8.3), ovary adult (RPKM 5.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Brf2 in Genome Data Viewer
    Location:
    8 A2; 8 15.91 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (27613367..27618743, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (27123339..27128715, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4994 Neighboring gene STARR-seq mESC enhancer starr_21013 Neighboring gene pyridoxal phosphate binding protein Neighboring gene predicted gene, 39151 Neighboring gene adhesion G protein-coupled receptor A2 Neighboring gene VISTA enhancer mm136 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:28239113-28239296 Neighboring gene RIKEN cDNA 4933416M07 gene Neighboring gene RAB11 family interacting protein 1 (class I) Neighboring gene glutamic-oxaloacetic transaminase 1-like 1 Neighboring gene STARR-seq mESC enhancer starr_21022

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase III type 3 promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase III type 3 promoter sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables TBP-class protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase III ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIIB complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIIB complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of transcription preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor IIIB 50 kDa subunit
    Names
    B-related factor 2
    BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025686.2 → NP_079962.1  transcription factor IIIB 50 kDa subunit

      See identical proteins and their annotated locations for NP_079962.1

      Status: VALIDATED

      Source sequence(s)
      AK012680
      Consensus CDS
      CCDS22211.1
      UniProtKB/Swiss-Prot
      Q3UAW9, Q9CZF0
      UniProtKB/TrEMBL
      A0A0R4J0C6
      Related
      ENSMUSP00000033877.5, ENSMUST00000033877.6
      Conserved Domains (2) summary
      COG1405
      Location:6 → 244
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      pfam08271
      Location:6 → 37
      TF_Zn_Ribbon; TFIIB zinc-binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      27613367..27618743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509180.4 → XP_006509243.1  transcription factor IIIB 50 kDa subunit isoform X1

      Conserved Domains (1) summary
      cl40454
      Location:1 → 28
      CYCLIN_SF; Cyclin box fold superfamily

    2. XM_036154240.1 → XP_036010133.1  transcription factor IIIB 50 kDa subunit isoform X1

      Conserved Domains (1) summary
      cl40454
      Location:1 → 28
      CYCLIN_SF; Cyclin box fold superfamily

    3. XM_006509181.4 → XP_006509244.1  transcription factor IIIB 50 kDa subunit isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UAW9.1 GenPept UniProtKB/Swiss-Prot:Q3UAW9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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