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    Rps27a ribosomal protein S27A [ Mus musculus (house mouse) ]

    Gene ID: 78294, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rps27aprovided by MGI
    Official Full Name
    ribosomal protein S27Aprovided by MGI
    Primary source
    MGI:MGI:1925544
    See related
    Ensembl:ENSMUSG00000020460 AllianceGenome:MGI:1925544
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ubb; Ubc; Uba52; 0610006J14Rik
    Summary
    Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in modification-dependent protein catabolic process; protein ubiquitination; and ribosomal small subunit biogenesis. Located in myelin sheath. Is active in synapse. Orthologous to several human genes including RPS27A (ribosomal protein S27a). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 445.0), CNS E11.5 (RPKM 386.0) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rps27a in Genome Data Viewer
    Location:
    11 A3.3; 11 16.79 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (29495842..29498040, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (29545842..29548040, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3936 Neighboring gene prolyl-tRNA synthetase domain containing 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:29426294-29426403 Neighboring gene mitochondrial translational initiation factor 2 Neighboring gene STARR-seq mESC enhancer starr_29024 Neighboring gene clathrin heavy chain linker domain containing 1 Neighboring gene 60S ribosomal protein L7-like Neighboring gene STARR-seq mESC enhancer starr_29025 Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Murine polyubiquitin mRNA sequence. Finch JS, et al. Nucleic Acids Res, 1990 Apr 11. PMID 2159627, Free PMC Article
    2. The HBx protein of hepatitis B virus regulates the expression, intracellular distribution and functions of ribosomal protein S27a. Fatima G, et al. J Gen Virol, 2012 Apr. PMID 22158882
    3. Molecular identification of a murine ubiquitin/60S ribosomal fusion protein and expression study in mouse kidney. Sun L, et al. Biochem Genet, 1999 Apr. PMID 10495888
    4. Evolution of the mouse polyubiquitin-C gene. Perelygin AA, et al. J Mol Evol, 2002 Aug. PMID 12107596
    5. Identification of genes differentially expressed in B16 murine melanoma sublines with different metastatic potentials. Ishiguro T, et al. Cancer Res, 1996 Feb 15. PMID 8631027

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. effector of HBx protein-mediated hepatocarcinogenesis
      Title: The HBx protein of hepatitis B virus regulates the expression, intracellular distribution and functions of ribosomal protein S27a.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation at postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation at presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in myelin sheath HDA PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin-ribosomal protein eS31 fusion protein
    Names
    ubiquitin carboxyl extension protein 80
    ubiquitin-40S ribosomal protein S27a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033865.1 → NP_001029037.1  ubiquitin-ribosomal protein eS31 fusion protein precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BX284634
      Consensus CDS
      CCDS24497.1
      UniProtKB/Swiss-Prot
      P49664, P62983, Q9D2W3
      UniProtKB/TrEMBL
      Q642L7
      Related
      ENSMUSP00000099908.4, ENSMUST00000102844.4
      Conserved Domains (2) summary
      cd01803
      Location:1 → 76
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      pfam01599
      Location:103 → 147
      Ribosomal_S27; Ribosomal protein S27a

    2. NM_024277.2 → NP_077239.1  ubiquitin-ribosomal protein eS31 fusion protein precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BX284634
      Consensus CDS
      CCDS24497.1
      UniProtKB/Swiss-Prot
      P49664, P62983, Q9D2W3
      UniProtKB/TrEMBL
      Q642L7
      Related
      ENSMUSP00000099909.5, ENSMUST00000102845.11
      Conserved Domains (2) summary
      cd01803
      Location:1 → 76
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      pfam01599
      Location:103 → 147
      Ribosomal_S27; Ribosomal protein S27a

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      29495842..29498040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62983.2 GenPept UniProtKB/Swiss-Prot:P62983

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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