Slc36a2 solute carrier family 36 (proton/amino acid symporter), member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc36a2provided by MGI
Official Full Name: solute carrier family 36 (proton/amino acid symporter), member 2provided by MGI
Primary source: MGI:MGI:1891430
See related: Ensembl:ENSMUSG00000020264 AllianceGenome:MGI:1891430
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PAT2; Tramd1; A530067G19Rik
Summary: Enables amino acid transmembrane transporter activity. Acts upstream of or within neutral amino acid transport and proton transmembrane transport. Located in endoplasmic reticulum membrane; plasma membrane; and recycling endosome membrane. Is expressed in several structures, including ear; face; heart; nervous system; and skeleton. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to human SLC36A2 (solute carrier family 36 member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in mammary gland adult (RPKM 166.7), subcutaneous fat pad adult (RPKM 116.6) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 32.16 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (55049294..55075924, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (55158468..55185099, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The amino acid transporter PAT2 and the purinergic receptor P2RX5 are cell surface markers expressed in classical brown and beige adipocytes.
Title: ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.
During the 14 day differentiation period the uptake of the prototype PAT2 substrate L-[(3)H]proline increased ~5-fold.
Title: Transport of L-proline by the proton-coupled amino acid transporter PAT2 in differentiated 3T3-L1 cells.
proton binding affinity to PAT2 is substrate-independent, favouring a sequential binding of proton followed by substrate
Title: Substrate specificity and transport mode of the proton-dependent amino acid transporter mPAT2.
Classification of lipid storage droplets based on this protein suggests that these organelles may serve specialized functions within individual cells.
Title: Association of PAT proteins with lipid storage droplets in term fetal membranes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

Slc36a2 (e-PCR), detects polymorphism
- UniSTS:507229

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-alanine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-alanine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-proline transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-proline transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables L-tyrosine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables amino acid:proton symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables amino acid:proton symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables amino acid:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid:proton symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glycine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables proline:proton symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables proline:proton symporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-alanine transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within L-alanine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in glycine transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of glycine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in proline transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proline transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proline transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proline transport	IDA Inferred from Direct Assay more info	PubMed
involved_in proton transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proton transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of proline transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of proton transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in vacuolar membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proton-coupled amino acid transporter 2

Names: proton/amino acid transporter 2; solute carrier family 36 member 2; tramdorin 1 (transmembrane domain rich protein); tramdorin-1; transmembrane domain rich protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153170.3 → NP_694810.2 proton-coupled amino acid transporter 2

See identical proteins and their annotated locations for NP_694810.2

Status: VALIDATED

Source sequence(s)

AK079053, AK086373, BB520081

Consensus CDS

CCDS24709.1

UniProtKB/Swiss-Prot

Q8BHK3, Q8BUB0, Q8JZP1

Related

ENSMUSP00000045613.6, ENSMUST00000039305.6

Conserved Domains (1) summary

cl00456
Location:48 → 458

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

55049294..55075924 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533324.5 → XP_006533387.1 proton-coupled amino acid transporter 2 isoform X1

Conserved Domains (1) summary

cl00456
Location:48 → 426

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006533325.5 → XP_006533388.1 proton-coupled amino acid transporter 2 isoform X3

Conserved Domains (1) summary

cl00456
Location:7 → 321

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_030246005.2 → XP_030101865.1 proton-coupled amino acid transporter 2 isoform X2

Conserved Domains (1) summary

cl00456
Location:1 → 396

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain