CAT5 putative monooxygenase CAT5 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: CAT5
Official Full Name: putative monooxygenase CAT5
Primary source: SGD:S000005651
Locus tag: YOR125C
See related: AllianceGenome:SGD:S000005651; FungiDB:YOR125C; VEuPathDB:YOR125C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: COQ7
Summary: Predicted to enable 3-demethoxyubiquinol 3-hydroxylase activity. Involved in ubiquinone biosynthetic process. Located in mitochondrial inner membrane. Used to study primary coenzyme Q10 deficiency 8. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 9 and primary coenzyme Q10 deficiency 8. Orthologous to human COQ7 (coenzyme Q7, hydroxylase). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

A non-canonical Puf3p-binding sequence regulates CAT5/COQ7 mRNA under both fermentable and respiratory conditions in budding yeast.
Title: A non-canonical Puf3p-binding sequence regulates CAT5/COQ7 mRNA under both fermentable and respiratory conditions in budding yeast.
Ptc7 has a role in inducing coenzyme Q biosynthesis by activating the hydroxylase Coq7
Title: The phosphatase Ptc7 induces coenzyme Q biosynthesis by activating the hydroxylase Coq7 in yeast.
Coq7p, and the lipid quinones (demethoxyubiquinone and Q) function to stabilize other Coq polypeptides
Title: Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 3-demethoxyubiquinol 3-hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-demethoxyubiquinol 3-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ubiquinone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquinone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquinone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extrinsic component of mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_014768.2

Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation