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    N4bp2 NEDD4 binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 333789, updated on 27-Nov-2024

    Summary

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    Official Symbol
    N4bp2provided by MGI
    Official Full Name
    NEDD4 binding protein 2provided by MGI
    Primary source
    MGI:MGI:2684414
    See related
    Ensembl:ENSMUSG00000037795 AllianceGenome:MGI:2684414
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B3bp; Gm868; Gm1791; E430014I16
    Summary
    Predicted to enable ATP binding activity; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; and DNA endonuclease activity. Located in cytosol. Is expressed in ovary and primary sex cord. Orthologous to human N4BP2 (NEDD4 binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 6.8), limb E14.5 (RPKM 6.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See N4bp2 in Genome Data Viewer
    Location:
    5 C3.1; 5 33.8 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (65909462..65987450)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (65760510..65830107)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40309 Neighboring gene ubiquitin-conjugating enzyme E2K Neighboring gene PDS5 cohesin associated factor A Neighboring gene STARR-seq mESC enhancer starr_13267 Neighboring gene predicted gene, 24399 Neighboring gene STARR-positive B cell enhancer ABC_E3578 Neighboring gene STARR-seq mESC enhancer starr_13273 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66156164-66156347 Neighboring gene predicted gene 5296 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66186562-66186763 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66242163-66242364 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66249264-66249516 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66254646-66254891 Neighboring gene predicted gene 3521 Neighboring gene ras homolog family member H

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. Murillas R, et al. J Biol Chem, 2002 Jan 25. PMID 11717310
    2. Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embryonic mouse gonad. McClive PJ, et al. Genesis, 2003 Oct. PMID 14595844
    3. Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination. Watanabe N, et al. J Biol Chem, 2003 Jul 11. PMID 12730195
    4. Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3. Villegas F, et al. Cell Stem Cell, 2019 Feb 7. PMID 30595499
    5. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NEDD4-binding protein 2
    Names
    Bcl3 binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024917.1 → NP_001020088.1  NEDD4-binding protein 2

      See identical proteins and their annotated locations for NP_001020088.1

      Status: VALIDATED

      Source sequence(s)
      AK173167, BC054549, CK637074, CX769144
      Consensus CDS
      CCDS19310.1
      UniProtKB/TrEMBL
      A0A0J9YUP5, F8VQG7
      Related
      ENSMUSP00000143807.2, ENSMUST00000201489.4
      Conserved Domains (4) summary
      smart00463
      Location:1596 → 1678
      SMR; Small MutS-related domain
      COG5099
      Location:92 → 253
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      pfam08590
      Location:1529 → 1590
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:372 → 498
      AAA_33; AAA domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      65909462..65987450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254611.2 → XP_030110471.1  NEDD4-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0J9YUP5
      Conserved Domains (5) summary
      smart00463
      Location:1676 → 1758
      SMR; Small MutS-related domain
      COG5099
      Location:172 → 333
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      cd14365
      Location:47 → 87
      CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
      pfam08590
      Location:1609 → 1670
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:452 → 578
      AAA_33; AAA domain

    2. XM_036165236.1 → XP_036021129.1  NEDD4-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0J9YUP5, F8VQG7
      Conserved Domains (4) summary
      smart00463
      Location:1596 → 1678
      SMR; Small MutS-related domain
      COG5099
      Location:92 → 253
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      pfam08590
      Location:1529 → 1590
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:372 → 498
      AAA_33; AAA domain

    3. XM_030254610.2 → XP_030110470.1  NEDD4-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0J9YUP5
      Conserved Domains (5) summary
      smart00463
      Location:1676 → 1758
      SMR; Small MutS-related domain
      COG5099
      Location:172 → 333
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      cd14365
      Location:47 → 87
      CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
      pfam08590
      Location:1609 → 1670
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:452 → 578
      AAA_33; AAA domain

    4. XM_006504004.5 → XP_006504067.1  NEDD4-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006504067.1

      UniProtKB/TrEMBL
      A0A0J9YUP5
      Conserved Domains (5) summary
      smart00463
      Location:1703 → 1785
      SMR; Small MutS-related domain
      COG5099
      Location:199 → 360
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      cd14365
      Location:74 → 114
      CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
      pfam08590
      Location:1636 → 1697
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:479 → 605
      AAA_33; AAA domain

    5. XM_030254615.2 → XP_030110475.1  NEDD4-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0J9YUP5, F8VQG7
      Conserved Domains (4) summary
      smart00463
      Location:1596 → 1678
      SMR; Small MutS-related domain
      COG5099
      Location:92 → 253
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      pfam08590
      Location:1529 → 1590
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:372 → 498
      AAA_33; AAA domain

    6. XM_006504003.3 → XP_006504066.1  NEDD4-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006504066.1

      UniProtKB/TrEMBL
      A0A0J9YUP5
      Conserved Domains (5) summary
      smart00463
      Location:1703 → 1785
      SMR; Small MutS-related domain
      COG5099
      Location:199 → 360
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      cd14365
      Location:74 → 114
      CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
      pfam08590
      Location:1636 → 1697
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:479 → 605
      AAA_33; AAA domain

    7. XM_006504007.4 → XP_006504070.1  NEDD4-binding protein 2 isoform X3

      See identical proteins and their annotated locations for XP_006504070.1

      UniProtKB/TrEMBL
      A0A0J9YUP5, F8VQG7
      Related
      ENSMUSP00000084519.4, ENSMUST00000087264.4
      Conserved Domains (4) summary
      smart00463
      Location:1596 → 1678
      SMR; Small MutS-related domain
      COG5099
      Location:92 → 253
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      pfam08590
      Location:1529 → 1590
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:372 → 498
      AAA_33; AAA domain

    8. XM_006504006.5 → XP_006504069.1  NEDD4-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0J9YUP5
      Conserved Domains (5) summary
      smart00463
      Location:1676 → 1758
      SMR; Small MutS-related domain
      COG5099
      Location:172 → 333
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      cd14365
      Location:47 → 87
      CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
      pfam08590
      Location:1609 → 1670
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:452 → 578
      AAA_33; AAA domain

    9. XM_030254614.1 → XP_030110474.1  NEDD4-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0J9YUP5, F8VQG7
      Conserved Domains (4) summary
      smart00463
      Location:1596 → 1678
      SMR; Small MutS-related domain
      COG5099
      Location:92 → 253
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      pfam08590
      Location:1529 → 1590
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:372 → 498
      AAA_33; AAA domain

    10. XM_030254609.2 → XP_030110469.1  NEDD4-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0J9YUP5
      Conserved Domains (5) summary
      smart00463
      Location:1676 → 1758
      SMR; Small MutS-related domain
      COG5099
      Location:172 → 333
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      cd14365
      Location:47 → 87
      CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
      pfam08590
      Location:1609 → 1670
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:452 → 578
      AAA_33; AAA domain

    11. XM_030254612.1 → XP_030110472.1  NEDD4-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0J9YUP5, F8VQG7
      Conserved Domains (4) summary
      smart00463
      Location:1596 → 1678
      SMR; Small MutS-related domain
      COG5099
      Location:92 → 253
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      pfam08590
      Location:1529 → 1590
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:372 → 498
      AAA_33; AAA domain

    12. XM_030254613.1 → XP_030110473.1  NEDD4-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0J9YUP5, F8VQG7
      Conserved Domains (4) summary
      smart00463
      Location:1596 → 1678
      SMR; Small MutS-related domain
      COG5099
      Location:92 → 253
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      pfam08590
      Location:1529 → 1590
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:372 → 498
      AAA_33; AAA domain

    13. XM_011240752.3 → XP_011239054.1  NEDD4-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011239054.1

      UniProtKB/TrEMBL
      A0A0J9YUP5
      Conserved Domains (5) summary
      smart00463
      Location:1703 → 1785
      SMR; Small MutS-related domain
      COG5099
      Location:199 → 360
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      cd14365
      Location:74 → 114
      CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
      pfam08590
      Location:1636 → 1697
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:479 → 605
      AAA_33; AAA domain

    14. XM_006504005.4 → XP_006504068.1  NEDD4-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006504068.1

      UniProtKB/TrEMBL
      A0A0J9YUP5
      Conserved Domains (5) summary
      smart00463
      Location:1703 → 1785
      SMR; Small MutS-related domain
      COG5099
      Location:199 → 360
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      cd14365
      Location:74 → 114
      CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
      pfam08590
      Location:1636 → 1697
      DUF1771; Domain of unknown function (DUF1771)
      pfam13671
      Location:479 → 605
      AAA_33; AAA domain

    15. XM_017320937.2 → XP_017176426.1  NEDD4-binding protein 2 isoform X4

      Conserved Domains (2) summary
      smart00463
      Location:1105 → 1187
      SMR; Small MutS-related domain
      pfam08590
      Location:1038 → 1099
      DUF1771; Domain of unknown function (DUF1771)
    Nucleotide Protein Strain
    Heading Accession and Version

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