Znhit1 zinc finger, HIT domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Znhit1provided by MGI
Official Full Name: zinc finger, HIT domain containing 1provided by MGI
Primary source: MGI:MGI:1917353
See related: Ensembl:ENSMUSG00000059518 AllianceGenome:MGI:1917353
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ZNFN4A1; 2700001K05Rik
Summary: Enables chromatin binding activity and histone deacetylase binding activity. Involved in several processes, including hematopoietic stem cell homeostasis; intestinal stem cell homeostasis; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within negative regulation of G0 to G1 transition; negative regulation of transcription by RNA polymerase II; and regulation of T cell proliferation. Located in nucleus. Is expressed in early conceptus; heart; and lens. Orthologous to human ZNHIT1 (zinc finger HIT-type containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Ubiquitous expression in testis adult (RPKM 63.4), adrenal adult (RPKM 44.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 76.09 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (137011048..137016813, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (136982194..136987959, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chromatin remodeler Znhit1 controls bone morphogenetic protein signaling in embryonic lung tissue branching.
Title: Chromatin remodeler Znhit1 controls bone morphogenetic protein signaling in embryonic lung tissue branching.
Znhit1 Regulates p21Cip1 to Control Mouse Lens Differentiation.
Title: Znhit1 Regulates p21Cip1 to Control Mouse Lens Differentiation.
Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression.
Title: Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression.
Critical role of Znhit1 for postnatal heart function and vacuolar cardiomyopathy.
Title: Critical role of Znhit1 for postnatal heart function and vacuolar cardiomyopathy.
Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers.
Title: Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers.
Znhit1 promotes the interaction between H2A.Z and YL1 (H2A.Z chaperone) by controlling YL1 phosphorylation. These results demonstrate that Znhit1/H2A.Z is essential for Lgr5+ stem cell maintenance and intestinal homeostasis.
Title: Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation.
These results identify SRCAP/H2A.Z-mediated chromatin remodelling as a key early event in muscle differentiation-specific gene expression.
Title: Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation.
These findings identified Znhit1 as a CDK6 regulator that plays an important role in cell proliferation.
Title: Znhit1 causes cell cycle arrest and down-regulates CDK6 expression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hematopoietic stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of G0 to G1 transition	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lymphoid progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription initiation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Swr1 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleosome	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger HIT domain-containing protein 1

Names: p18 Hamlet; zinc finger protein, subfamily 4A (HIT domain containing), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310747.1 → NP_001297676.1 zinc finger HIT domain-containing protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (2) has a longer, distinct N-terminus than isoform 1.

Source sequence(s)

AA002885, AI426440, AI841783, BY084904

Consensus CDS

CCDS80438.1

UniProtKB/Swiss-Prot

Q8R331, Q9CZS6

UniProtKB/TrEMBL

G8JL39

Related

ENSMUSP00000083103.6, ENSMUST00000085941.12

Conserved Domains (2) summary

pfam04438
Location:113 → 140

zf-HIT; HIT zinc finger

cl02154
Location:79 → 135

YL1_C; YL1 nuclear protein C-terminal domain
NM_001310748.1 → NP_001297677.1 zinc finger HIT domain-containing protein 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (3) has a longer, distinct N-terminus than isoform 1.

Source sequence(s)

AC147987

Consensus CDS

CCDS80437.1

UniProtKB/TrEMBL

D3YZ33, G8JL39

Related

ENSMUSP00000106720.2, ENSMUST00000111091.8

Conserved Domains (2) summary

pfam04438
Location:117 → 144

zf-HIT; HIT zinc finger

cl02154
Location:83 → 139

YL1_C; YL1 nuclear protein C-terminal domain
NM_027318.4 → NP_081594.1 zinc finger HIT domain-containing protein 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the shortest isoform (1).

Source sequence(s)

AI841783, AK080799, CX202132

Consensus CDS

CCDS39329.1

UniProtKB/TrEMBL

A0A0R4J1S6, D3YZ34

Related

ENSMUSP00000115929.2, ENSMUST00000156963.8

Conserved Domains (2) summary

pfam04438
Location:112 → 139

zf-HIT; HIT zinc finger

cl02154
Location:78 → 134

YL1_C; YL1 nuclear protein C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

137011048..137016813 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504497.5 → XP_006504560.1 zinc finger HIT domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

D3YZ33, G8JL39

Conserved Domains (2) summary

pfam04438
Location:117 → 144

zf-HIT; HIT zinc finger

cl02154
Location:83 → 139

YL1_C; YL1 nuclear protein C-terminal domain