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    GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 26088, updated on 9-Dec-2024

    Summary

    Official Symbol
    GGA1provided by HGNC
    Official Full Name
    golgi associated, gamma adaptin ear containing, ARF binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:17842
    See related
    Ensembl:ENSG00000100083 MIM:606004; AllianceGenome:HGNC:17842
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 36.8), spleen (RPKM 8.3) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GGA1 in Genome Data Viewer
    Location:
    22q13.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (37608834..37633564)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38068513..38094844)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38004841..38029571)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37957123-37957729 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37957730-37958337 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37958338-37958944 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37959472-37959972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37959973-37960473 Neighboring gene CDC42 effector protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37963831-37964482 Neighboring gene HNF1 motif-containing MPRA enhancer 93 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37965972-37966480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37967120-37967620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37967621-37968121 Neighboring gene galectin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18977 Neighboring gene Sharpr-MPRA regulatory region 7746 Neighboring gene CRISPRi-validated cis-regulatory element chr22.1757 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18979 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13688 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38005225-38005846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18982 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38029311-38030184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18984 Neighboring gene Sharpr-MPRA regulatory region 10481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13690 Neighboring gene SH3 domain binding protein 1 Neighboring gene PDXP divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18985 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18986 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38054605-38055106 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38055933-38056444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38056445-38056955 Neighboring gene pyridoxal phosphatase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Genome-wide shRNA screening identifies GGA1, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed
    Pr55(Gag) gag GGA1 overexpression severely reduces virus particle production by impairing Gag trafficking to the membrane, an effect that requires the MA domain of Gag PubMed
    gag GGA1-induced, but not GGA2- or GGA3-induced, compartments accumulate unprocessed Gag and virus-like particles PubMed
    Vpr vpr Expression of a patient-derived HIV-1 Vpr protein reveals a significant reduction in Vpr nuclear import. Vpr F72L mutation is responsible for this decreased Vpr nuclear import and the F72L mutant is co-localized with gamma-adaptin in the Golgi apparatus PubMed
    matrix gag GGA1 overexpression severely reduces virus particle production by impairing Gag trafficking to the membrane, which requires the MA domain of Gag PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in Golgi apparatus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome membrane TAS
    Traceable Author Statement
    more info
     
    located_in endosome membrane TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ADP-ribosylation factor-binding protein GGA1
    Names
    ADP-ribosylation factor binding protein 1
    gamma-adaptin related protein 1
    golgi-localized, gamma ear-containing, ARF-binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001560.3NP_001001560.1  ADP-ribosylation factor-binding protein GGA1 isoform 2

      See identical proteins and their annotated locations for NP_001001560.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks 2 in-frame exons in the coding region, as compared to variant 1. The encoded isoform 2 thus lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK075256, AL110219, BC044629
      Consensus CDS
      CCDS33643.1
      UniProtKB/Swiss-Prot
      Q9UJY5
      Related
      ENSP00000321288.8, ENST00000325180.12
      Conserved Domains (3) summary
      smart00809
      Location:430544
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd03567
      Location:9147
      VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
      cl03906
      Location:210277
      GAT_SF; GAT domain found in eukaryotic ADP-ribosylation factor (Arf)-binding proteins (GGAs), metazoan myb protein 1 (Tom1)-like proteins, and similar proteins
    2. NM_001172687.2NP_001166158.1  ADP-ribosylation factor-binding protein GGA1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an in-frame segment in the coding region, as compared to variant 1. The resulting isoform (4) lacks an internal segment of 4 aa, as compared to isoform 1.
      Source sequence(s)
      AK075256, AL110219
      UniProtKB/Swiss-Prot
      Q9UJY5
      Conserved Domains (4) summary
      smart00809
      Location:513627
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd03567
      Location:9147
      VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
      cd14239
      Location:210299
      GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
      cl00753
      Location:180234
      DUF327; Protein of unknown function (DUF327)
    3. NM_001172688.2NP_001166159.1  ADP-ribosylation factor-binding protein GGA1 isoform 5

      See identical proteins and their annotated locations for NP_001166159.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has an alternate 5' sequence, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (5) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK122898, AL110219
      Consensus CDS
      CCDS54526.1
      UniProtKB/Swiss-Prot
      Q9UJY5
      Related
      ENSP00000385287.1, ENST00000406772.5
      Conserved Domains (4) summary
      smart00809
      Location:444558
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd14239
      Location:137225
      GAT_GGA1_GGA2; canonical GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
      pfam18308
      Location:96134
      GGA_N-GAT; GGA N-GAT domain
      cl02544
      Location:174
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily
    4. NM_001363771.2NP_001350700.1  ADP-ribosylation factor-binding protein GGA1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL110219, CR456493
      Consensus CDS
      CCDS87022.1
      Related
      ENSP00000371175.5, ENST00000381756.9
      Conserved Domains (3) summary
      smart00809
      Location:534648
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd03567
      Location:9164
      VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
      cd14239
      Location:227316
      GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
    5. NM_013365.5NP_037497.1  ADP-ribosylation factor-binding protein GGA1 isoform 1

      See identical proteins and their annotated locations for NP_037497.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK075256, AL110219
      Consensus CDS
      CCDS13951.1
      UniProtKB/Swiss-Prot
      A8K3D3, B0QYR7, Q5R3N1, Q5TG07, Q6IC75, Q86YA9, Q8NCS6, Q9BW94, Q9UG00, Q9UGW0, Q9UGW1, Q9UJY5
      Related
      ENSP00000341344.4, ENST00000343632.9
      Conserved Domains (4) summary
      smart00809
      Location:517631
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd03567
      Location:9147
      VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
      cd14239
      Location:210299
      GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
      cl00753
      Location:180234
      DUF327; Protein of unknown function (DUF327)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      37608834..37633564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024452214.2XP_024307982.1  ADP-ribosylation factor-binding protein GGA1 isoform X3

      Conserved Domains (3) summary
      smart00809
      Location:447561
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd03567
      Location:9164
      VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
      cl03906
      Location:227294
      GAT_SF; GAT domain found in eukaryotic ADP-ribosylation factor (Arf)-binding proteins (GGAs), metazoan myb protein 1 (Tom1)-like proteins, and similar proteins
    2. XM_047441327.1XP_047297283.1  ADP-ribosylation factor-binding protein GGA1 isoform X7

    3. XM_006724229.2XP_006724292.1  ADP-ribosylation factor-binding protein GGA1 isoform X4

      See identical proteins and their annotated locations for XP_006724292.1

      UniProtKB/Swiss-Prot
      Q9UJY5
      Conserved Domains (4) summary
      smart00809
      Location:444558
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd14239
      Location:137225
      GAT_GGA1_GGA2; canonical GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
      pfam18308
      Location:96134
      GGA_N-GAT; GGA N-GAT domain
      cl02544
      Location:174
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily
    4. XM_011530123.3XP_011528425.1  ADP-ribosylation factor-binding protein GGA1 isoform X1

      Conserved Domains (4) summary
      smart00809
      Location:526640
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd03567
      Location:7156
      VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
      cd14239
      Location:219308
      GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
      cl00753
      Location:189243
      DUF327; Protein of unknown function (DUF327)
    5. XM_005261518.3XP_005261575.1  ADP-ribosylation factor-binding protein GGA1 isoform X2

      Conserved Domains (4) summary
      smart00809
      Location:509623
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd03567
      Location:7139
      VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
      cd14239
      Location:202291
      GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
      cl00753
      Location:172226
      DUF327; Protein of unknown function (DUF327)
    6. XM_047441323.1XP_047297279.1  ADP-ribosylation factor-binding protein GGA1 isoform X5

    7. XM_047441325.1XP_047297281.1  ADP-ribosylation factor-binding protein GGA1 isoform X4

      Conserved Domains (4) summary
      smart00809
      Location:444558
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd14239
      Location:137225
      GAT_GGA1_GGA2; canonical GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
      pfam18308
      Location:96134
      GGA_N-GAT; GGA N-GAT domain
      cl02544
      Location:174
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily
    8. XM_024452216.2XP_024307984.1  ADP-ribosylation factor-binding protein GGA1 isoform X4

      Conserved Domains (4) summary
      smart00809
      Location:444558
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd14239
      Location:137225
      GAT_GGA1_GGA2; canonical GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
      pfam18308
      Location:96134
      GGA_N-GAT; GGA N-GAT domain
      cl02544
      Location:174
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily
    9. XM_047441324.1XP_047297280.1  ADP-ribosylation factor-binding protein GGA1 isoform X4

      Conserved Domains (4) summary
      smart00809
      Location:444558
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd14239
      Location:137225
      GAT_GGA1_GGA2; canonical GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
      pfam18308
      Location:96134
      GGA_N-GAT; GGA N-GAT domain
      cl02544
      Location:174
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily
    10. XM_024452215.2XP_024307983.1  ADP-ribosylation factor-binding protein GGA1 isoform X4

      Conserved Domains (4) summary
      smart00809
      Location:444558
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd14239
      Location:137225
      GAT_GGA1_GGA2; canonical GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
      pfam18308
      Location:96134
      GGA_N-GAT; GGA N-GAT domain
      cl02544
      Location:174
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily
    11. XM_047441326.1XP_047297282.1  ADP-ribosylation factor-binding protein GGA1 isoform X4

      Conserved Domains (4) summary
      smart00809
      Location:444558
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd14239
      Location:137225
      GAT_GGA1_GGA2; canonical GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
      pfam18308
      Location:96134
      GGA_N-GAT; GGA N-GAT domain
      cl02544
      Location:174
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily
    12. XM_024452217.2XP_024307985.1  ADP-ribosylation factor-binding protein GGA1 isoform X6

      Conserved Domains (3) summary
      smart00809
      Location:380494
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd14239
      Location:73162
      GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
      cl00753
      Location:4397
      DUF327; Protein of unknown function (DUF327)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      38068513..38094844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325510.1XP_054181485.1  ADP-ribosylation factor-binding protein GGA1 isoform X8

    2. XM_054325509.1XP_054181484.1  ADP-ribosylation factor-binding protein GGA1 isoform X8

    3. XM_054325514.1XP_054181489.1  ADP-ribosylation factor-binding protein GGA1 isoform X3

    4. XM_054325512.1XP_054181487.1  ADP-ribosylation factor-binding protein GGA1 isoform X9

    5. XM_054325517.1XP_054181492.1  ADP-ribosylation factor-binding protein GGA1 isoform X10

    6. XM_054325521.1XP_054181496.1  ADP-ribosylation factor-binding protein GGA1 isoform X7

    7. XM_054325513.1XP_054181488.1  ADP-ribosylation factor-binding protein GGA1 isoform X2

    8. XM_054325516.1XP_054181491.1  ADP-ribosylation factor-binding protein GGA1 isoform X4

    9. XM_054325518.1XP_054181493.1  ADP-ribosylation factor-binding protein GGA1 isoform X5

    10. XM_054325511.1XP_054181486.1  ADP-ribosylation factor-binding protein GGA1 isoform X1

    11. XM_054325515.1XP_054181490.1  ADP-ribosylation factor-binding protein GGA1 isoform X4

    12. XM_054325520.1XP_054181495.1  ADP-ribosylation factor-binding protein GGA1 isoform X4

    13. XM_054325519.1XP_054181494.1  ADP-ribosylation factor-binding protein GGA1 isoform X6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001001561.2: Suppressed sequence

      Description
      NM_001001561.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain intronic sequence at its 3' end.