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    Cnep1r1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 382030, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cnep1r1provided by MGI
    Official Full Name
    CTD nuclear envelope phosphatase 1 regulatory subunit 1provided by MGI
    Primary source
    MGI:MGI:1921981
    See related
    Ensembl:ENSMUSG00000036810 AllianceGenome:MGI:1921981
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NEP1-R1; Tmem188; 5033428A16Rik
    Summary
    Predicted to enable protein phosphatase regulator activity. Predicted to be involved in positive regulation of triglyceride biosynthetic process and protein localization to nucleus. Predicted to be located in cytosol and nuclear membrane. Predicted to be part of Nem1-Spo7 phosphatase complex. Predicted to be active in cytoplasm. Orthologous to human CNEP1R1 (CTD nuclear envelope phosphatase 1 regulatory subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 12.6), CNS E11.5 (RPKM 10.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cnep1r1 in Genome Data Viewer
    Location:
    8 C3; 8 43.06 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (88845344..88861825)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (88118716..88135197)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39217 Neighboring gene STARR-seq mESC enhancer starr_22225 Neighboring gene predicted gene 2716 Neighboring gene STARR-seq mESC enhancer starr_22226 Neighboring gene RAB11a, member RAS oncogene family pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1765 Neighboring gene microRNA 7071 Neighboring gene HEAT repeat containing 3 Neighboring gene terminal nucleotidyltransferase 4B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity. Xia P, et al. Nat Immunol, 2018 Feb. PMID 29292386
    2. Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway. Han S, et al. J Biol Chem, 2012 Jan 27. PMID 22134922, Free PMC Article
    3. Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Horiuchi K, et al. Cell Rep, 2018 Apr 3. PMID 29617656
    4. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway.
      Title: Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC171143

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein phosphatase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of triglyceride biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Nem1-Spo7 phosphatase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Nem1-Spo7 phosphatase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Nem1-Spo7 phosphatase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nuclear envelope phosphatase-regulatory subunit 1
    Names
    transmembrane protein 188

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029074.3 → NP_083350.2  nuclear envelope phosphatase-regulatory subunit 1

      See identical proteins and their annotated locations for NP_083350.2

      Status: VALIDATED

      Source sequence(s)
      AC126034, AK146578, BY124150
      Consensus CDS
      CCDS52628.1
      UniProtKB/Swiss-Prot
      A7E1Z4, Q3UJ81, Q8VEG8, Q9D3Q4
      UniProtKB/TrEMBL
      D3Z6J3
      Related
      ENSMUSP00000092839.4, ENSMUST00000095214.10
      Conserved Domains (1) summary
      pfam09771
      Location:5 → 122
      Tmemb_18A; Transmembrane protein 188

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      88845344..88861825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248420.2 → XP_011246722.1  nuclear envelope phosphatase-regulatory subunit 1 isoform X1

      UniProtKB/TrEMBL
      D3Z6J3
      Conserved Domains (1) summary
      pfam09771
      Location:5 → 112
      Tmemb_18A; Transmembrane protein 188

    2. XM_011248421.2 → XP_011246723.1  nuclear envelope phosphatase-regulatory subunit 1 isoform X2

      See identical proteins and their annotated locations for XP_011246723.1

      UniProtKB/TrEMBL
      D3Z6J3
      Related
      ENSMUSP00000113207.2, ENSMUST00000117775.2
      Conserved Domains (1) summary
      pfam09771
      Location:5 → 112
      Tmemb_18A; Transmembrane protein 188
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UJ81.1 GenPept UniProtKB/Swiss-Prot:Q3UJ81

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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