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    Prh1 proline rich protein HaeIII subfamily 1 [ Mus musculus (house mouse) ]

    Gene ID: 19131, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prh1provided by MGI
    Official Full Name
    proline rich protein HaeIII subfamily 1provided by MGI
    Primary source
    MGI:MGI:97773
    See related
    Ensembl:ENSMUSG00000059934 AllianceGenome:MGI:97773
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MP2; Prp
    Summary
    This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The expression of this gene is dramatically induced in the parotid and submandibular glands of mice by beta-adrenergic stimulation. The encoded protein serves an important dental function by protecting mice against toxic dietary polyphenols such as tannins and influence the visco-elastic properties of the mucus. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 6. [provided by RefSeq, Nov 2015]
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    Genomic context

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    See Prh1 in Genome Data Viewer
    Location:
    6 64.03 cM; 6 G1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (132546805..132549364)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (132569842..132572401)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5154 Neighboring gene STARR-seq mESC enhancer starr_17506 Neighboring gene STARR-seq mESC enhancer starr_17507 Neighboring gene STARR-seq mESC enhancer starr_17508 Neighboring gene predicted gene, 18326 Neighboring gene STARR-seq mESC enhancer starr_17509 Neighboring gene STARR-seq mESC enhancer starr_17510 Neighboring gene STARR-seq mESC enhancer starr_17511 Neighboring gene STARR-seq mESC enhancer starr_17512 Neighboring gene proline rich protein 2 Neighboring gene RIKEN cDNA A630073D07 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Salivary proline-rich protein genes on chromosome 8 of mouse. Azen EA, et al. Science, 1984 Nov 23. PMID 6095444
    2. Codominant expression of genes coding for different sets of inducible salivary polypeptides associated with parotid hypertrophy in two inbred mouse strains. López-Solís RO, et al. J Cell Biochem, 2005 May 1. PMID 15723342
    3. Cyclic AMP regulation of mouse proline-rich protein gene expression: isoproterenol induction of AP-1 transcription factors in parotid glands. Zhou J, et al. Arch Biochem Biophys, 1997 Feb 1. PMID 9015393
    4. High-resolution genetic mapping of the sucrose octaacetate taste aversion (Soa) locus on mouse Chromosome 6. Bachmanov AA, et al. Mamm Genome, 2001 Sep. PMID 11641717, Free PMC Article
    5. Assignment of the proline-rich protein gene Prp2 (alias D6Mit13) to mouse chromosome 6G1 by in situ hybridization. Azen EA, et al. Cytogenet Cell Genet, 2000. PMID 10894928

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    proline-rich protein HaeIII subfamily 1
    Names
    proline-rich protein MP-2
    proline-rich salivary protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011174.4 → NP_035304.4  proline-rich protein HaeIII subfamily 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC124523
      Consensus CDS
      CCDS57460.1
      UniProtKB/TrEMBL
      D3Z1V5, H3BLQ6
      Related
      ENSMUSP00000135877.2, ENSMUST00000177523.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      132546805..132549364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05142.2 GenPept UniProtKB/Swiss-Prot:P05142

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