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    Gpr108 G protein-coupled receptor 108 [ Mus musculus (house mouse) ]

    Gene ID: 78308, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gpr108provided by MGI
    Official Full Name
    G protein-coupled receptor 108provided by MGI
    Primary source
    MGI:MGI:1925558
    See related
    Ensembl:ENSMUSG00000005823 AllianceGenome:MGI:1925558
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lustr2; 1810015L19Rik
    Summary
    Involved in negative regulation of toll-like receptor signaling pathway. Located in cis-Golgi network membrane. Orthologous to human GPR108 (G protein-coupled receptor 108). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 41.2), adrenal adult (RPKM 30.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr108 in Genome Data Viewer
    Location:
    17 D; 17 29.74 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57541914..57555743, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57234914..57248743, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor (ligand) superfamily, member 14 Neighboring gene complement component 3 Neighboring gene STARR-positive B cell enhancer ABC_E8688 Neighboring gene microRNA 6978 Neighboring gene thyroid hormone receptor interactor 10 Neighboring gene STARR-positive B cell enhancer ABC_E54 Neighboring gene STARR-positive B cell enhancer ABC_E8689 Neighboring gene STARR-positive B cell enhancer ABC_E615 Neighboring gene SH2 domain containing 3A pseudogene Neighboring gene predicted gene, 52326

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity. Zhao M, et al. Cell Rep, 2023 Jun 27. PMID 37330913
    2. GPR108, an NF-κB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses. Dong D, et al. PLoS One, 2018. PMID 30332431, Free PMC Article
    3. Human GPR107 and murine Gpr108 are members of the LUSTR family of proteins found in both plants and animals, having similar topology to G-protein coupled receptors. Edgar AJ. DNA Seq, 2007 Jun. PMID 17454009
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity.
      Title: A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity.
    2. GPR108, an NF-kappaB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses.
      Title: GPR108, an NF-κB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses.
    3. Murine Gpr108 gene is located at 17C-D and spans 12.8 kb; Gpr108 cDNA encodes a 562 residue protein that has 49% identity to human GPR107.[Gpr108 protein]
      Title: Human GPR107 and murine Gpr108 are members of the LUSTR family of proteins found in both plants and animals, having similar topology to G-protein coupled receptors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of toll-like receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of toll-like receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cis-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein GPR108
    Names
    lung seven transmembrane receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308072.1 → NP_001295001.1  protein GPR108 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001295001.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK047364, AK159313, BB611826, BE981210
      Consensus CDS
      CCDS89128.1
      UniProtKB/Swiss-Prot
      Q91WD0
      Related
      ENSMUSP00000005975.8, ENSMUST00000005975.8
      Conserved Domains (1) summary
      pfam06814
      Location:234 → 522
      Lung_7-TM_R; Lung seven transmembrane receptor

    2. NM_001308074.1 → NP_001295003.1  protein GPR108 isoform 3

      See identical proteins and their annotated locations for NP_001295003.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' terminal exon and an alternate splice site in an internal exon, compared to variant 1. This results in a distinct 5' UTR and the use of a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK047364, AK159313, BE981210, BG079632
      UniProtKB/Swiss-Prot
      Q91WD0
      Conserved Domains (1) summary
      pfam06814
      Location:67 → 354
      Lung_7-TM_R; Lung seven transmembrane receptor

    3. NM_030084.4 → NP_084360.2  protein GPR108 isoform 1 precursor

      See identical proteins and their annotated locations for NP_084360.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK159313, BB611826, BE981210
      Consensus CDS
      CCDS28929.1
      UniProtKB/Swiss-Prot
      Q8BXE9, Q91WD0, Q925B1
      Related
      ENSMUSP00000156910.2, ENSMUST00000233568.2
      Conserved Domains (1) summary
      pfam06814
      Location:241 → 529
      Lung_7-TM_R; Lung seven transmembrane receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      57541914..57555743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317727.2 → XP_017173216.1  protein GPR108 isoform X1

      Conserved Domains (1) summary
      pfam06814
      Location:67 → 354
      Lung_7-TM_R; Lung seven transmembrane receptor

    2. XM_017317726.2 → XP_017173215.1  protein GPR108 isoform X1

      Conserved Domains (1) summary
      pfam06814
      Location:67 → 354
      Lung_7-TM_R; Lung seven transmembrane receptor

    3. XM_011246719.1 → XP_011245021.1  protein GPR108 isoform X1

      See identical proteins and their annotated locations for XP_011245021.1

      Conserved Domains (1) summary
      pfam06814
      Location:67 → 354
      Lung_7-TM_R; Lung seven transmembrane receptor

    RNA

    1. XR_003952213.2 RNA Sequence

    2. XR_876592.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001308073.1: Suppressed sequence

      Description
      NM_001308073.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WD0.1 GenPept UniProtKB/Swiss-Prot:Q91WD0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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