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    Bex4 brain expressed X-linked 4 [ Mus musculus (house mouse) ]

    Gene ID: 406217, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bex4provided by MGI
    Official Full Name
    brain expressed X-linked 4provided by MGI
    Primary source
    MGI:MGI:3606746
    See related
    Ensembl:ENSMUSG00000047844 AllianceGenome:MGI:3606746
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables molecular function inhibitor activity. Involved in negative regulation of protein ubiquitination and regulation of mitotic cell cycle. Located in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; gut; sensory organ; and submandibular gland primordium. Orthologous to human BEX4 (brain expressed X-linked 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in placenta adult (RPKM 179.6), liver E14 (RPKM 115.6) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bex4 in Genome Data Viewer
    Location:
    X F1; X 57.4 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (135039745..135041192)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (136138996..136140443)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene brain expressed X-linked 2 Neighboring gene nuclear RNA export factor 3 Neighboring gene RIKEN cDNA 5730412P04 gene Neighboring gene transcription elongation factor A (SII)-like 8 Neighboring gene microRNA 6383

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BEX4 upregulation alters Sertoli cell growth properties and protein expression profiles: An explanation for cadmium-induced testicular Sertoli cell injury. Yu W, et al. J Biochem Mol Toxicol, 2017 Jul. PMID 28295929
    2. Immunolocalization of Bex protein in the mouse brain and olfactory system. Koo JH, et al. J Comp Neurol, 2005 Jun 20. PMID 15861462
    3. Transcriptome of early embryonic invasion at implantation sites in a murine model. Moreno-Moya JM, et al. Reprod Fertil Dev, 2015 May 5. PMID 25940376
    4. Gene targeting study reveals unexpected expression of brain-expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice. Ito K, et al. J Biol Chem, 2014 Oct 24. PMID 25143383, Free PMC Article
    5. Characterization of the Bex gene family in humans, mice, and rats. Alvarez E, et al. Gene, 2005 Aug 29. PMID 15958283

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. present study provides the first evidence that BEX4 upregulation induces alterations in Sertoli cell growth properties and protein expression profiles, which may be an explanation for Cd-induced testicular Sertoli cell injury
      Title: BEX4 upregulation alters Sertoli cell growth properties and protein expression profiles: An explanation for cadmium-induced testicular Sertoli cell injury.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular function inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tubulin deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein BEX4
    Names
    BEX1-like protein 1
    brain expressed gene 4
    brain-expressed X-linked protein 4 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359569.1 → NP_001346498.1  protein BEX4

      Status: VALIDATED

      Source sequence(s)
      AL671914, BC090663
      Consensus CDS
      CCDS30414.1
      UniProtKB/Swiss-Prot
      Q9CWT2
      UniProtKB/TrEMBL
      Q14BB8
      Conserved Domains (1) summary
      pfam04538
      Location:26 → 114
      BEX; Brain expressed X-linked like family

    2. NM_001359570.1 → NP_001346499.1  protein BEX4

      Status: VALIDATED

      Source sequence(s)
      AK010400, AL118340, AL671914, BC090663
      Consensus CDS
      CCDS30414.1
      UniProtKB/Swiss-Prot
      Q9CWT2
      UniProtKB/TrEMBL
      Q14BB8
      Conserved Domains (1) summary
      pfam04538
      Location:26 → 114
      BEX; Brain expressed X-linked like family

    3. NM_212457.3 → NP_997622.1  protein BEX4

      See identical proteins and their annotated locations for NP_997622.1

      Status: VALIDATED

      Source sequence(s)
      AK010400, AL671914, BC090663
      Consensus CDS
      CCDS30414.1
      UniProtKB/Swiss-Prot
      Q9CWT2
      UniProtKB/TrEMBL
      Q14BB8
      Related
      ENSMUSP00000112226.2, ENSMUST00000116527.2
      Conserved Domains (1) summary
      pfam04538
      Location:26 → 114
      BEX; Brain expressed X-linked like family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      135039745..135041192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWT2.1 GenPept UniProtKB/Swiss-Prot:Q9CWT2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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