Bex2 brain expressed X-linked 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bex2provided by MGI
Official Full Name: brain expressed X-linked 2provided by MGI
Primary source: MGI:MGI:1338017
See related: Ensembl:ENSMUSG00000042750 AllianceGenome:MGI:1338017
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bex1; REX-3
Summary: Enables molecular function inhibitor activity. Involved in negative regulation of protein ubiquitination. Predicted to be part of transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including gut; lung; nervous system; sensory organ; and skeletal musculature. Orthologous to human BEX1 (brain expressed X-linked 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Note: The Bex1 and Bex2 genes appear to have undergone gene conversion, exchanging bits of coding sequence with each other. This complicates determination of orthologs in other species. For this reason, gene name assignments may not be consistent between species. [06 Dec 2023]
Expression: Biased expression in CNS E18 (RPKM 143.6), placenta adult (RPKM 136.7) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F1; X 57.37 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (134967314..134968985, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (136066565..136068236, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

enhanced STAT3/NF-kappaB-BEX2-VEGF signaling pathway contributes to hyperactive mTOR-induced tumorigenesis
Title: Brain-expressed X-linked 2 Is Pivotal for Hyperactive Mechanistic Target of Rapamycin (mTOR)-mediated Tumorigenesis.
These results suggest the significance and potential applications of Bex2 in studies of endocrine and stem/progenitor cells.
Title: Gene targeting study reveals unexpected expression of brain-expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice.
Expression of ALDH1A2, BEX2, EGR2, CCL3 and PLAU are upregulated in Toxoplasma gondiisusceptible C57BL/6 mice.
Title: Gene expression profiles in genetically different mice infected with Toxoplasma gondii: ALDH1A2, BEX2, EGR2, CCL3 and PLAU.
Bex immunoreactivity (ir) was primarily localized to neuronal cells within the olfactory epithelium, bulb, peri/paraventricular nuclei, suprachiasmatic nucleus, hypothalamus, thalamus, hippocampus, and cerebellum.
Title: Immunolocalization of Bex protein in the mouse brain and olfactory system.
We report the identification of an olfactory marker protein binding partner, Bex2, by phage-display screening of an olfactory mucosal cDNA-library
Title: Identification of members of the Bex gene family as olfactory marker protein (OMP) binding partners.
Bex1 and 2 have been characterized as interacting partners of the olfactory marker protein (OMP). Bex immunoreactivity (ir) was primarily localized to neuronal cells within several regions of the brain.
Title: Immunolocalization of Bex protein in the mouse brain and olfactory system.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126864 (e-PCR)
- UniSTS:209752

Bex2 (e-PCR), detects polymorphism
- UniSTS:141172

Bex2 (e-PCR), detects polymorphism
- UniSTS:256653

RH125463 (e-PCR)
- UniSTS:162282

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular function inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein BEX2

Names: brain-expressed X-linked protein 1 homolog; brain-expressed X-linked protein 2 homolog; protein BEX1; reduced expression protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.