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    Rbak RB-associated KRAB zinc finger [ Mus musculus (house mouse) ]

    Gene ID: 57782, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbakprovided by MGI
    Official Full Name
    RB-associated KRAB zinc fingerprovided by MGI
    Primary source
    MGI:MGI:1927369
    See related
    Ensembl:ENSMUSG00000061898 AllianceGenome:MGI:1927369
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human RBAK (RB associated KRAB zinc finger). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 5.1), CNS E11.5 (RPKM 4.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rbak in Genome Data Viewer
    Location:
    5 G2; 5 81.98 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143157941..143166530, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (143172186..143180775, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7291 Neighboring gene RB-associated KRAB zinc finger downstream neighbor (non-protein coding) Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:143942516-143942699 Neighboring gene speedy/RINGO cell cycle regulator family, member E4B Neighboring gene speedy/RINGO cell cycle regulator family, member E4A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel Kruppel-associated box family transcriptional repressor that interacts with the retinoblastoma gene product, RB. Skapek SX, et al. J Biol Chem, 2000 Mar 10. PMID 10702291
    2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RB-associated KRAB zinc finger protein
    Names
    RB-associated KRAB repressor
    zinc finger protein 769

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045482.2 → NP_001038947.1  RB-associated KRAB zinc finger protein

      See identical proteins and their annotated locations for NP_001038947.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC123686, AK051009, CN699599
      Consensus CDS
      CCDS19835.1
      UniProtKB/Swiss-Prot
      Q6PB38, Q8BQC8, Q9JKU4
      Related
      ENSMUSP00000059273.5, ENSMUST00000049861.11
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:340 → 699
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:316 → 336
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:314 → 336
      zf-C2H2; Zinc finger, C2H2 type

    2. NM_001359235.1 → NP_001346164.1  RB-associated KRAB zinc finger protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC123686
      Consensus CDS
      CCDS19835.1
      UniProtKB/Swiss-Prot
      Q6PB38, Q8BQC8, Q9JKU4
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:340 → 699
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:316 → 336
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:314 → 336
      zf-C2H2; Zinc finger, C2H2 type

    3. NM_021326.3 → NP_067301.1  RB-associated KRAB zinc finger protein

      See identical proteins and their annotated locations for NP_067301.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AC123686, AK051009
      Consensus CDS
      CCDS19835.1
      UniProtKB/Swiss-Prot
      Q6PB38, Q8BQC8, Q9JKU4
      Related
      ENSMUSP00000128731.2, ENSMUST00000165318.4
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:340 → 699
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:316 → 336
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:314 → 336
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      143157941..143166530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BQC8.1 GenPept UniProtKB/Swiss-Prot:Q8BQC8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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