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    Zkscan5 zinc finger with KRAB and SCAN domains 5 [ Mus musculus (house mouse) ]

    Gene ID: 22757, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zkscan5provided by MGI
    Official Full Name
    zinc finger with KRAB and SCAN domains 5provided by MGI
    Primary source
    MGI:MGI:107533
    See related
    Ensembl:ENSMUSG00000055991 AllianceGenome:MGI:107533
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp95; hKraba1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including ear; early embryo; genitourinary system; and nervous system. Orthologous to human ZKSCAN5 (zinc finger with KRAB and SCAN domains 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.5), testis adult (RPKM 3.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zkscan5 in Genome Data Viewer
    Location:
    5 G2; 5 85.14 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (145141349..145158562)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (145204559..145221752)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit f Neighboring gene zinc finger with KRAB and SCAN domains 14 Neighboring gene STARR-positive B cell enhancer ABC_E1316 Neighboring gene STARR-positive B cell enhancer ABC_E533 Neighboring gene STARR-positive B cell enhancer ABC_E4805 Neighboring gene zinc finger protein 655 Neighboring gene predicted gene 9710

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Three novel spermatogenesis-specific zinc finger genes. Weissig H, et al. FEBS Lett, 2003 Jul 17. PMID 12860387
    2. Comparative analysis of a conserved zinc finger gene cluster on human chromosome 19q and mouse chromosome 7. Shannon M, et al. Genomics, 1996 Apr 1. PMID 8617494
    3. Constraint and divergence of global gene expression in the mammalian embryo. Spies N, et al. Elife, 2015 Apr 14. PMID 25871848, Free PMC Article
    4. Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Tang F, et al. PLoS One, 2011. PMID 21731673, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cloning and characterization of its expression during spermatogenesis
      Title: Three novel spermatogenesis-specific zinc finger genes.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein with KRAB and SCAN domains 5
    Names
    zfp-95
    zinc finger protein 95

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167944.2 → NP_001161416.1  zinc finger protein with KRAB and SCAN domains 5 isoform 2

      See identical proteins and their annotated locations for NP_001161416.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two coding exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC127411
      Consensus CDS
      CCDS51697.1
      UniProtKB/TrEMBL
      Q6PAK4
      Related
      ENSMUSP00000031601.8, ENSMUST00000031601.8
      Conserved Domains (6) summary
      smart00431
      Location:47 → 155
      SCAN; leucine rich region
      COG5048
      Location:250 → 671
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:469 → 489
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:467 → 489
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:47 → 134
      SCAN; SCAN domain
      pfam13465
      Location:310 → 333
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001359187.2 → NP_001346116.1  zinc finger protein with KRAB and SCAN domains 5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC127411
      Conserved Domains (5) summary
      smart00431
      Location:47 → 155
      SCAN; leucine rich region
      COG5048
      Location:308 → 729
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:527 → 547
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:763 → 787
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:220 → 240
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    3. NM_001359188.2 → NP_001346117.1  zinc finger protein with KRAB and SCAN domains 5 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate splice junction in the 5' end compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC127411
      Conserved Domains (4) summary
      cd07765
      Location:71 → 105
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:174 → 595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:393 → 413
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:629 → 653
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001359189.2 → NP_001346118.1  zinc finger protein with KRAB and SCAN domains 5 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains two alternate splice junctions compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC127411
      Conserved Domains (3) summary
      cd07765
      Location:33 → 67
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:136 → 557
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:355 → 375
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001359190.2 → NP_001346119.1  zinc finger protein with KRAB and SCAN domains 5 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains an alternate splice junction in the 5' end and lacks two coding exons compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AC127411
      Conserved Domains (3) summary
      COG5048
      Location:101 → 522
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:320 → 340
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:556 → 580
      zf-H2C2_2; Zinc-finger double domain

    6. NM_001359191.2 → NP_001346120.1  zinc finger protein with KRAB and SCAN domains 5 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (7) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC127411
      Conserved Domains (5) summary
      smart00431
      Location:47 → 155
      SCAN; leucine rich region
      cd07765
      Location:220 → 254
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      sd00017
      Location:343 → 363
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:341 → 363
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:355 → 380
      zf-H2C2_2; Zinc-finger double domain

    7. NM_001359192.2 → NP_001346121.1  zinc finger protein with KRAB and SCAN domains 5 isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks two coding exons and uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (8) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AC127411
      Conserved Domains (4) summary
      smart00431
      Location:47 → 155
      SCAN; leucine rich region
      sd00017
      Location:270 → 290
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:268 → 290
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:282 → 307
      zf-H2C2_2; Zinc-finger double domain

    8. NM_001425461.1 → NP_001412390.1  zinc finger protein with KRAB and SCAN domains 5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC127411

    9. NM_016683.3 → NP_057892.2  zinc finger protein with KRAB and SCAN domains 5 isoform 1

      See identical proteins and their annotated locations for NP_057892.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC127411
      Consensus CDS
      CCDS39386.1
      UniProtKB/Swiss-Prot
      E9QLY2, Q9Z1D8
      Related
      ENSMUSP00000082814.4, ENSMUST00000085671.10
      Conserved Domains (7) summary
      smart00431
      Location:47 → 155
      SCAN; leucine rich region
      COG5048
      Location:323 → 744
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:542 → 562
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:540 → 562
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:220 → 251
      KRAB; KRAB box
      pfam02023
      Location:47 → 134
      SCAN; SCAN domain
      pfam13465
      Location:383 → 406
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      145141349..145158562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504822.2 → XP_006504885.1  zinc finger protein with KRAB and SCAN domains 5 isoform X2

      See identical proteins and their annotated locations for XP_006504885.1

      Conserved Domains (3) summary
      COG5048
      Location:20 → 441
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:239 → 259
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:475 → 499
      zf-H2C2_2; Zinc-finger double domain

    2. XM_011241010.1 → XP_011239312.1  zinc finger protein with KRAB and SCAN domains 5 isoform X2

      See identical proteins and their annotated locations for XP_011239312.1

      Conserved Domains (3) summary
      COG5048
      Location:20 → 441
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:239 → 259
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:475 → 499
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1D8.2 GenPept UniProtKB/Swiss-Prot:Q9Z1D8

    Gene LinkOut

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