Sprr1a small proline-rich protein 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sprr1aprovided by MGI
Official Full Name: small proline-rich protein 1Aprovided by MGI
Primary source: MGI:MGI:106660
See related: Ensembl:ENSMUSG00000050359 AllianceGenome:MGI:106660
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SPR1a; mSPRR1A
Summary: Predicted to be a structural constituent of skin epidermis. Predicted to be involved in keratinocyte differentiation and peptide cross-linking. Located in cell periphery. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and nose. Orthologous to human SPRR1A (small proline rich protein 1A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in bladder adult (RPKM 594.4), stomach adult (RPKM 355.2) and 1 other tissue See more
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Genomic context

Location:: 3 F1; 3 40.14 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (92391261..92393188, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (92483954..92485881, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPRR1A is a key downstream effector of MiR-150 during both maladaptive cardiac remodeling in mice and human cardiac fibroblast activation.
Title: SPRR1A is a key downstream effector of MiR-150 during both maladaptive cardiac remodeling in mice and human cardiac fibroblast activation.
Cardiomyocyte microRNA-150 confers cardiac protection and directly represses proapoptotic small proline-rich protein 1A.
Title: Cardiomyocyte microRNA-150 confers cardiac protection and directly represses proapoptotic small proline-rich protein 1A.
MiR-463-3p inhibits tibial nerve regeneration via post-transcriptional suppression of SPRR1A
Title: MiR-463-3p inhibits tibial nerve regeneration via post-transcriptional suppression of SPRR1A.
Carbon monoxide modulates alpha-smooth muscle actin and small proline rich-1a expression in fibrosis.
Title: Carbon monoxide modulates alpha-smooth muscle actin and small proline rich-1a expression in fibrosis.
Results suggest that SPRR1A is a regeneration-associated gene and that SPRR1A provides a valuable marker to assess the regenerative potential of injured neurons.
Title: Expression of the regeneration-associated protein SPRR1A in primary sensory neurons and spinal cord of the adult mouse following peripheral and central injury.
Small proline-rich repeat protein 1A is expressed by axotomized neurons and promotes axonal outgrowth
Title: Small proline-rich repeat protein 1A is expressed by axotomized neurons and promotes axonal outgrowth.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

General gene information

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Markers

Sprr1a (e-PCR), detects polymorphism
- UniSTS:507242

AI528815 (e-PCR)
- UniSTS:165273

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of skin epidermis	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in keratinization	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in peptide cross-linking	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cornified envelope	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cornifin-A

Names: SPR1 A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.