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    Nudc nudC nuclear distribution protein [ Mus musculus (house mouse) ]

    Gene ID: 18221, updated on 13-Jan-2025

    Summary

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    Official Symbol
    Nudcprovided by MGI
    Official Full Name
    nudC nuclear distribution proteinprovided by MGI
    Primary source
    MGI:MGI:106014
    See related
    Ensembl:ENSMUSG00000028851 AllianceGenome:MGI:106014
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SIG-92; Silg92
    Summary
    Predicted to enable unfolded protein binding activity. Predicted to be involved in several processes, including mitotic metaphase chromosome alignment; mitotic spindle organization; and protein folding. Predicted to be located in cytosol; midbody; and mitotic spindle. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human NUDC (nuclear distribution C, dynein complex regulator). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 117.1), liver E14 (RPKM 77.3) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nudc in Genome Data Viewer
    Location:
    4 D2.3; 4 66.25 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133259853..133273338, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133532542..133546027, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4676 Neighboring gene TMF1-regulated nuclear protein 1 Neighboring gene predicted gene, 42323 Neighboring gene keratinocyte differentiation factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E2127 Neighboring gene nuclear receptor subfamily 0, group B, member 2 Neighboring gene G patch domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NUDC is critical for rod photoreceptor function, maintenance, and survival. Garner MA, et al. FASEB J, 2024 Mar 15. PMID 38441532,
    2. The human homologue of the Aspergillus nuclear migration gene nudC is preferentially expressed in dividing cells and ciliated epithelia. Gocke CD, et al. Histochem Cell Biol, 2000 Oct. PMID 11131094
    3. Isolation and characterization of nudC from mouse macrophages, a gene implicated in the inflammatory response through the regulation of PAF-AH(I) activity. Riera J, et al. FEBS Lett, 2007 Jun 26. PMID 17555748
    4. The lissencephaly protein Lis1 is present in motile mammalian cilia and requires outer arm dynein for targeting to Chlamydomonas flagella. Pedersen LB, et al. J Cell Sci, 2007 Mar 1. PMID 17314247
    5. Molecular cloning and characterization of the human NUDC gene. Matsumoto N, et al. Hum Genet, 1999 Jun. PMID 10453739

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NUDC is critical for rod photoreceptor function, maintenance, and survival.
      Title: NUDC is critical for rod photoreceptor function, maintenance, and survival.
    2. An essential role of mNUDC for anterograde transport of dynein and dynactin by kinesin-1.
      Title: mNUDC is required for plus-end-directed transport of cytoplasmic dynein and dynactins by kinesin-1.
    3. A novel function for mammalian nudC and nudC-like genes as anti-inflammatory proteins.
      Title: Isolation and characterization of nudC from mouse macrophages, a gene implicated in the inflammatory response through the regulation of PAF-AH(I) activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nuclear migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear migration protein nudC
    Names
    nuclear distribution gene C homolog
    nuclear distribution protein C homolog
    silica-induced gene 92 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010948.3 → NP_035078.1  nuclear migration protein nudC

      Status: VALIDATED

      Source sequence(s)
      AK032673, BE948227, DV652222
      Consensus CDS
      CCDS18750.1
      UniProtKB/Swiss-Prot
      O35685, Q3UJS7
      Related
      ENSMUSP00000030665.7, ENSMUST00000030665.7
      Conserved Domains (3) summary
      cd06492
      Location:173 → 259
      p23_mNUDC_like; p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) ...
      pfam14050
      Location:9 → 60
      Nudc_N; N-terminal conserved domain of Nudc
      pfam16273
      Location:98 → 144
      NuDC; Nuclear distribution C domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      133259853..133273338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35685.1 GenPept UniProtKB/Swiss-Prot:O35685

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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