Parp6 poly (ADP-ribose) polymerase family, member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Parp6provided by MGI
Official Full Name: poly (ADP-ribose) polymerase family, member 6provided by MGI
Primary source: MGI:MGI:1914537
See related: Ensembl:ENSMUSG00000025237 AllianceGenome:MGI:1914537
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ARTD17; PARP-6; 1700119G14Rik; 2310028P13Rik; 3110038K10Rik; C030013N01Rik
Summary: Predicted to enable NAD+-protein ADP-ribosyltransferase activity; kinase binding activity; and protein serine/threonine kinase activator activity. Predicted to be involved in endoplasmic reticulum unfolded protein response; positive regulation of dendrite morphogenesis; and protein auto-ADP-ribosylation. Predicted to be active in endoplasmic reticulum tubular network and nuclear envelope. Is expressed in nervous system and sensory organ. Orthologous to human PARP6 (poly(ADP-ribose) polymerase family member 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E18 (RPKM 29.0), CNS E14 (RPKM 27.4) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 32.02 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (59524473..59557573)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (59617147..59650290)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of PARP6 Function in Knockout Mice and Patients with Developmental Delay.
Title: Characterization of PARP6 Function in Knockout Mice and Patients with Developmental Delay.
PARP6 is a regulator of dendrite morphogenesis, supporting a role for mono-ADP-ribosylation in neurons during development.
Title: PARP6 is a Regulator of Hippocampal Dendritic Morphogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_5107-5108:1031667431:1 (e-PCR)
- UniSTS:269458

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD+-protein-cysteine ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-cysteine ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in protein auto-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in protein auto-ADP-ribosylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum tubular network	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein mono-ADP-ribosyltransferase PARP6

Names: ADP-ribosyltransferase diphtheria toxin-like 17; poly [ADP-ribose] polymerase 6

NP_001192168.1

EC 2.4.2.30

NP_084198.2

EC 2.4.2.30

XP_006511438.1

EC 2.4.2.30

XP_006511443.1

EC 2.4.2.30

XP_011241097.1

EC 2.4.2.30

XP_011241098.1

EC 2.4.2.30

XP_011241099.1

EC 2.4.2.30

XP_011241100.1

EC 2.4.2.30

XP_011241101.1

EC 2.4.2.30

XP_011241102.1

EC 2.4.2.30

XP_011241103.1

EC 2.4.2.30

XP_017169016.1

EC 2.4.2.30

XP_017169017.1

EC 2.4.2.30

XP_017169018.1

EC 2.4.2.30

XP_030100371.1

EC 2.4.2.30

XP_030100372.1

EC 2.4.2.30

XP_030100373.1

EC 2.4.2.30

XP_030100380.1

EC 2.4.2.30

XP_030100381.1

EC 2.4.2.30

XP_030100382.1

EC 2.4.2.30

XP_036011091.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205239.1 → NP_001192168.1 protein mono-ADP-ribosyltransferase PARP6 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AC160637, BC062096, BQ442721

Consensus CDS

CCDS57680.1

UniProtKB/Swiss-Prot

Q6P6P7, Q8BVW1

UniProtKB/TrEMBL

G5E856

Related

ENSMUSP00000026267.9, ENSMUST00000026267.16

Conserved Domains (1) summary

cd01341
Location:470 → 594

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
NM_029922.3 → NP_084198.2 protein mono-ADP-ribosyltransferase PARP6 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC160637, BC052064, BQ442721

Consensus CDS

CCDS90586.1

UniProtKB/Swiss-Prot

Q6P6P7, Q8BVW1

UniProtKB/TrEMBL

A0A0R4J0T1

Related

ENSMUSP00000063065.8, ENSMUST00000050483.15

Conserved Domains (1) summary

cd01341
Location:450 → 574

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

RNA

NR_038074.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC123817, AC160637, AK076321, BC062096, BQ442721

Related

ENSMUST00000216351.2
NR_038075.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC123817, AC160637, BQ442721

Related

ENSMUST00000167091.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

59524473..59557573

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242795.3 → XP_011241097.1 protein mono-ADP-ribosyltransferase PARP6 isoform X1

UniProtKB/Swiss-Prot

Q6P6P7, Q8BVW1

Conserved Domains (1) summary

cd01341
Location:471 → 606

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_011242798.3 → XP_011241100.1 protein mono-ADP-ribosyltransferase PARP6 isoform X3

UniProtKB/Swiss-Prot

Q6P6P7, Q8BVW1

Conserved Domains (1) summary

cd01341
Location:471 → 595

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_011242797.3 → XP_011241099.1 protein mono-ADP-ribosyltransferase PARP6 isoform X2

UniProtKB/Swiss-Prot

Q6P6P7, Q8BVW1

Conserved Domains (1) summary

cd01341
Location:470 → 605

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_011242801.3 → XP_011241103.1 protein mono-ADP-ribosyltransferase PARP6 isoform X7

UniProtKB/Swiss-Prot

Q6P6P7, Q8BVW1

Conserved Domains (1) summary

cd01341
Location:429 → 564

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_030244520.2 → XP_030100380.1 protein mono-ADP-ribosyltransferase PARP6 isoform X8

UniProtKB/Swiss-Prot

Q6P6P7, Q8BVW1

Conserved Domains (1) summary

cd01341
Location:429 → 553

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_030244521.2 → XP_030100381.1 protein mono-ADP-ribosyltransferase PARP6 isoform X9

UniProtKB/Swiss-Prot

Q6P6P7, Q8BVW1

Conserved Domains (1) summary

cd01341
Location:428 → 552

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_011242799.3 → XP_011241101.1 protein mono-ADP-ribosyltransferase PARP6 isoform X5

UniProtKB/Swiss-Prot

Q6P6P7, Q8BVW1

Conserved Domains (1) summary

cd01341
Location:451 → 586

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_011242800.3 → XP_011241102.1 protein mono-ADP-ribosyltransferase PARP6 isoform X6

UniProtKB/Swiss-Prot

Q6P6P7, Q8BVW1

Conserved Domains (1) summary

cd01341
Location:451 → 575

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_017313527.2 → XP_017169016.1 protein mono-ADP-ribosyltransferase PARP6 isoform X1

UniProtKB/Swiss-Prot

Q6P6P7, Q8BVW1

Conserved Domains (1) summary

cd01341
Location:471 → 606

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_017313529.2 → XP_017169018.1 protein mono-ADP-ribosyltransferase PARP6 isoform X3

UniProtKB/Swiss-Prot

Q6P6P7, Q8BVW1

Conserved Domains (1) summary

cd01341
Location:471 → 595

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_017313528.2 → XP_017169017.1 protein mono-ADP-ribosyltransferase PARP6 isoform X2

UniProtKB/Swiss-Prot

Q6P6P7, Q8BVW1

Conserved Domains (1) summary

cd01341
Location:470 → 605

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_011242796.2 → XP_011241098.1 protein mono-ADP-ribosyltransferase PARP6 isoform X1

UniProtKB/Swiss-Prot

Q6P6P7, Q8BVW1

Conserved Domains (1) summary

cd01341
Location:471 → 606

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_006511375.4 → XP_006511438.1 protein mono-ADP-ribosyltransferase PARP6 isoform X1

UniProtKB/Swiss-Prot

Q6P6P7, Q8BVW1

Conserved Domains (1) summary

cd01341
Location:471 → 606

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_030244511.2 → XP_030100371.1 protein mono-ADP-ribosyltransferase PARP6 isoform X3

UniProtKB/Swiss-Prot

Q6P6P7, Q8BVW1

Conserved Domains (1) summary

cd01341
Location:471 → 595

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_030244513.2 → XP_030100373.1 protein mono-ADP-ribosyltransferase PARP6 isoform X4

UniProtKB/Swiss-Prot

Q6P6P7, Q8BVW1

UniProtKB/TrEMBL

G5E856

Conserved Domains (1) summary

cd01341
Location:470 → 594

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_030244522.2 → XP_030100382.1 protein mono-ADP-ribosyltransferase PARP6 isoform X9

UniProtKB/Swiss-Prot

Q6P6P7, Q8BVW1

Conserved Domains (1) summary

cd01341
Location:428 → 552

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_030244512.2 → XP_030100372.1 protein mono-ADP-ribosyltransferase PARP6 isoform X4

UniProtKB/Swiss-Prot

Q6P6P7, Q8BVW1

UniProtKB/TrEMBL

G5E856

Conserved Domains (1) summary

cd01341
Location:470 → 594

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_006511380.5 → XP_006511443.1 protein mono-ADP-ribosyltransferase PARP6 isoform X10

Conserved Domains (1) summary

cd01341
Location:336 → 471

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
XM_036155198.1 → XP_036011091.1 protein mono-ADP-ribosyltransferase PARP6 isoform X11

Conserved Domains (1) summary

cd01341
Location:335 → 459

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...