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    Mus81 MUS81 structure-specific endonuclease subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293678, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mus81provided by RGD
    Official Full Name
    MUS81 structure-specific endonuclease subunitprovided by RGD
    Primary source
    RGD:1311957
    See related
    EnsemblRapid:ENSRNOG00000020617 AllianceGenome:RGD:1311957
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 3'-flap endonuclease activity. Predicted to contribute to crossover junction DNA endonuclease activity. Predicted to be involved in DNA metabolic process; mitotic intra-S DNA damage checkpoint signaling; and osteoblast proliferation. Predicted to act upstream of or within DNA catabolic process and response to intra-S DNA damage checkpoint signaling. Predicted to be located in nucleolus. Predicted to be part of Holliday junction resolvase complex. Predicted to be active in nucleus and replication fork. Orthologous to human MUS81 (MUS81 structure-specific endonuclease subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 82.5), Heart (RPKM 71.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mus81 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212219793..212225214, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (202790295..202796008, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (220862474..220867973, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cathepsin W Neighboring gene EGF containing fibulin extracellular matrix protein 2 Neighboring gene cofilin 1 Neighboring gene sorting nexin 32 Neighboring gene MAGE family member B10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response. Xing M, et al. Oncotarget, 2015 Nov 10. PMID 26415217, Free PMC Article
    2. FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress. Fugger K, et al. Nat Commun, 2013. PMID 23361013
    3. Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Muñoz IM, et al. Mol Cell, 2009 Jul 10. PMID 19595721
    4. Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Svendsen JM, et al. Cell, 2009 Jul 10. PMID 19596235, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112911

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-flap endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3'-flap endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to crossover junction DNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables crossover junction DNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via break-induced replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in osteoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in osteoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replication fork processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to intra-S DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to intra-S DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Holliday junction resolvase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Holliday junction resolvase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of endodeoxyribonuclease complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in replication fork IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    crossover junction endonuclease MUS81
    Names
    MUS81 endonuclease homolog
    NP_001020816.1
    XP_006230809.1
    XP_008758328.1
    XP_008758329.1
    XP_038964323.1
    XP_038964328.1
    XP_063142919.1
    XP_063142923.1
    XP_063142925.1
    XP_063142926.1
    XP_063142927.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025645.1 → NP_001020816.1  crossover junction endonuclease MUS81

      See identical proteins and their annotated locations for NP_001020816.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098853
      UniProtKB/Swiss-Prot
      Q4KM32
      UniProtKB/TrEMBL
      A0A8I5ZVS5, A6HZ68
      Related
      ENSRNOP00000028015.6, ENSRNOT00000028015.8
      Conserved Domains (1) summary
      pfam02732
      Location:273 → 415
      ERCC4; ERCC4 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      212219793..212225214 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286855.1 → XP_063142925.1  crossover junction endonuclease MUS81 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZVS5, A0A8I6AEG6
      Related
      ENSRNOP00000090515.1, ENSRNOT00000093884.2

    2. XM_008760106.4 → XP_008758328.1  crossover junction endonuclease MUS81 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVS5, A0A8L2QFD5
      Conserved Domains (1) summary
      pfam02732
      Location:285 → 427
      ERCC4; ERCC4 domain

    3. XM_039108395.2 → XP_038964323.1  crossover junction endonuclease MUS81 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZVS5
      Conserved Domains (2) summary
      cd20074
      Location:278 → 431
      XPF_nuclease_Mus81; XPF-like nuclease domain of Mus81
      cd21036
      Location:130 → 219
      WH_MUS81; winged helix domain found in crossover junction endonuclease MUS81 and similar proteins

    4. XM_063286853.1 → XP_063142923.1  crossover junction endonuclease MUS81 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZVS5

    5. XM_063286849.1 → XP_063142919.1  crossover junction endonuclease MUS81 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZVS5

    6. XM_008760107.3 → XP_008758329.1  crossover junction endonuclease MUS81 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZVS5
      Conserved Domains (1) summary
      pfam02732
      Location:278 → 420
      ERCC4; ERCC4 domain

    7. XM_063286856.1 → XP_063142926.1  crossover junction endonuclease MUS81 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZVS5

    8. XM_006230747.5 → XP_006230809.1  crossover junction endonuclease MUS81 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZVS5, A0A8I6AMQ1
      Related
      ENSRNOP00000095258.1, ENSRNOT00000113189.2
      Conserved Domains (1) summary
      pfam02732
      Location:251 → 383
      ERCC4; ERCC4 domain

    9. XM_039108400.2 → XP_038964328.1  crossover junction endonuclease MUS81 isoform X9

      Conserved Domains (2) summary
      cd20074
      Location:278 → 431
      XPF_nuclease_Mus81; XPF-like nuclease domain of Mus81
      cd21036
      Location:130 → 219
      WH_MUS81; winged helix domain found in crossover junction endonuclease MUS81 and similar proteins

    10. XM_063286857.1 → XP_063142927.1  crossover junction endonuclease MUS81 isoform X10

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KM32.1 GenPept UniProtKB/Swiss-Prot:Q4KM32

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