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    Pigw phosphatidylinositol glycan anchor biosynthesis, class W [ Rattus norvegicus (Norway rat) ]

    Gene ID: 378774, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pigwprovided by RGD
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Wprovided by RGD
    Primary source
    RGD:727962
    See related
    EnsemblRapid:ENSRNOG00000027857 AllianceGenome:RGD:727962
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable glucosaminyl-phosphatidylinositol O-acyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process and protein localization to plasma membrane. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 5. Orthologous to human PIGW (phosphatidylinositol glycan anchor biosynthesis class W). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 75.4), Spleen (RPKM 69.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pigw in Genome Data Viewer
    Location:
    10q26
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (70246904..70248412, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (69746996..69782656, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (72194774..72198415, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2I, pseudogene 4 Neighboring gene dehydrogenase/reductase 11 Neighboring gene gametogenetin binding protein 2 Neighboring gene zinc finger, HIT-type containing 3 Neighboring gene myosin XIX Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glucosaminyl-phosphatidylinositol O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositol-glycan biosynthesis class W protein
    Names
    PIG-W
    phosphatidylinositol glycan, class W

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194461.1NP_919443.1  phosphatidylinositol-glycan biosynthesis class W protein

      See identical proteins and their annotated locations for NP_919443.1

      Status: PROVISIONAL

      Source sequence(s)
      AB097817
      UniProtKB/Swiss-Prot
      Q7TSN4
      UniProtKB/TrEMBL
      A6HHM4, D4AA75, F1LNX4
      Related
      ENSRNOP00000060195.2, ENSRNOT00000029769.5
      Conserved Domains (1) summary
      cl02109
      Location:4501
      GWT1; GWT1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      70246904..70248412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)