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    Fchsd1 FCH and double SH3 domains 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307482, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fchsd1provided by RGD
    Official Full Name
    FCH and double SH3 domains 1provided by RGD
    Primary source
    RGD:1308240
    See related
    EnsemblRapid:ENSRNOG00000039415 AllianceGenome:RGD:1308240
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable lipid binding activity. Predicted to be involved in membrane organization; neuromuscular synaptic transmission; and positive regulation of actin filament polymerization. Predicted to be located in cuticular plate. Predicted to be active in neuromuscular junction and recycling endosome. Orthologous to human FCHSD1 (FCH and double SH3 domains 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 50.0), Brain (RPKM 48.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fchsd1 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (30043466..30056326, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (29793899..29804533, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (31096815..31109077, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene diaphanous-related formin 1 Neighboring gene uncharacterized LOC120098325 Neighboring gene histone deacetylase 3 Neighboring gene RELT-like 2 Neighboring gene ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 Neighboring gene uncharacterized LOC134483010

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Formation of membrane ridges and scallops by the F-BAR protein Nervous Wreck. Becalska AN, et al. Mol Biol Cell, 2013 Aug. PMID 23761074, Free PMC Article
    2. FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro. Cao H, et al. PLoS One, 2013. PMID 23437151, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuromuscular synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cuticular plate ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    F-BAR and double SH3 domains protein 1
    Names
    FCH and double SH3 domains protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109881.3 → NP_001103351.1  F-BAR and double SH3 domains protein 1

      See identical proteins and their annotated locations for NP_001103351.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6J3E2, D4AD36
      Related
      ENSRNOP00000026381.6, ENSRNOT00000026381.9
      Conserved Domains (3) summary
      cd11761
      Location:470 → 526
      SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
      cl12013
      Location:16 → 275
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:550 → 607
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      30043466..30056326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254635.5 → XP_006254697.1  F-BAR and double SH3 domains protein 1 isoform X1

      Conserved Domains (3) summary
      cd11761
      Location:468 → 524
      SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
      cl12013
      Location:16 → 273
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:548 → 605
      SH3; Src Homology 3 domain superfamily

    RNA

    1. XR_005496036.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107392.1: Suppressed sequence

      Description
      NM_001107392.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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