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    Mier2 MIER family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362841, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mier2provided by RGD
    Official Full Name
    MIER family member 2provided by RGD
    Primary source
    RGD:1307278
    See related
    EnsemblRapid:ENSRNOG00000000175 AllianceGenome:RGD:1307278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307278
    Summary
    Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to contribute to histone deacetylase activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in nucleoplasm. Orthologous to human MIER2 (MIER family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 48.7), Spleen (RPKM 25.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mier2 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10804238..10819979)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (10153501..10169381)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (13039759..13055632)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479817 Neighboring gene sperm microtubule associated protein 2 Neighboring gene phospholipid phosphatase 2 Neighboring gene uncharacterized LOC120093534

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential HDAC1 and 2 Recruitment by Members of the MIER Family. Derwish R, et al. PLoS One, 2017. PMID 28046085, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mesoderm induction early response protein 2
    Names
    mesoderm induction early response 1, family member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394321.2 → NP_001381250.1  mesoderm induction early response protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6K904, D3ZR39
      Conserved Domains (2) summary
      cd11661
      Location:301 → 345
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:196 → 246
      ELM2; ELM2 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10804238..10819979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594913.3 → XP_017450402.1  mesoderm induction early response protein 2 isoform X4

      UniProtKB/TrEMBL
      A6K903, D3ZR39
      Conserved Domains (3) summary
      smart00717
      Location:324 → 370
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:325 → 369
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:220 → 270
      ELM2; ELM2 domain

    2. XM_039079407.2 → XP_038935335.2  mesoderm induction early response protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JT20, D3ZR39

    3. XM_039079408.2 → XP_038935336.2  mesoderm induction early response protein 2 isoform X2

      UniProtKB/TrEMBL
      D3ZR39
      Related
      ENSRNOP00000068538.3, ENSRNOT00000090048.3

    4. XM_063263747.1 → XP_063119817.1  mesoderm induction early response protein 2 isoform X5

      UniProtKB/TrEMBL
      A6K906

    5. XM_017594912.3 → XP_017450401.1  mesoderm induction early response protein 2 isoform X3

    6. XM_063263749.1 → XP_063119819.1  mesoderm induction early response protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JT20, D3ZR39

    7. XM_039079411.2 → XP_038935339.1  mesoderm induction early response protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JT20, D3ZR39
      Conserved Domains (2) summary
      cd11661
      Location:289 → 333
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:184 → 234
      ELM2; ELM2 domain

    8. XM_063263748.1 → XP_063119818.1  mesoderm induction early response protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JT20, D3ZR39

    9. XM_039079409.2 → XP_038935337.1  mesoderm induction early response protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JT20, D3ZR39
      Conserved Domains (2) summary
      cd11661
      Location:289 → 333
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:184 → 234
      ELM2; ELM2 domain

    10. XM_039079410.2 → XP_038935338.1  mesoderm induction early response protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JT20, D3ZR39
      Conserved Domains (2) summary
      cd11661
      Location:289 → 333
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:184 → 234
      ELM2; ELM2 domain

    11. XM_017594914.3 → XP_017450403.1  mesoderm induction early response protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JT20, D3ZR39
      Conserved Domains (2) summary
      cd11661
      Location:289 → 333
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:184 → 234
      ELM2; ELM2 domain

    12. XM_017594915.3 → XP_017450404.1  mesoderm induction early response protein 2 isoform X2

      UniProtKB/TrEMBL
      D3ZR39

    13. XM_039079412.2 → XP_038935340.1  mesoderm induction early response protein 2 isoform X6

      UniProtKB/TrEMBL
      A6K907, D3ZR39
      Conserved Domains (2) summary
      cd11661
      Location:241 → 285
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:136 → 186
      ELM2; ELM2 domain

    RNA

    1. XR_010052993.1 RNA Sequence

    2. XR_010052994.1 RNA Sequence

    3. XR_010052995.1 RNA Sequence

    4. XR_010052996.1 RNA Sequence

    5. XR_010052998.1 RNA Sequence

    6. XR_010052997.1 RNA Sequence

    7. XR_010053000.1 RNA Sequence

    8. XR_010052999.1 RNA Sequence

    9. XR_010053001.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108737.1: Suppressed sequence

      Description
      NM_001108737.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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