CHGB chromogranin B [Homo sapiens (human)] - Gene

Summary

Official Symbol: CHGBprovided by HGNC
Official Full Name: chromogranin Bprovided by HGNC
Primary source: HGNC:HGNC:1930
See related: Ensembl:ENSG00000089199 MIM:118920; AllianceGenome:HGNC:1930
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SCG1
Summary: This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]
Expression: Biased expression in adrenal (RPKM 1898.3) and stomach (RPKM 91.0) See more
Orthologs: mouse all
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Genomic context

Location:: 20p12.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (5911510..5925353)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (5951841..5965685)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (5892156..5905999)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mechanisms of chromogranin B-regulated Cl- homeostasis.
Title: The mechanisms of chromogranin B-regulated Cl- homeostasis.
Chromogranin B in blood serum of patients with neuroendocrine tumors.", trans "capital HA, Cyrillicsmall er, Cyrillicsmall o, Cyrillicsmall em, Cyrillicsmall o, Cyrillicsmall ghe, Cyrillicsmall er, Cyrillicsmall a, Cyrillicsmall en, Cyrillicsmall i, Cyrillicsmall en, Cyrillic capital VE, Cyrillic small ve, Cyrillic small es, Cyrillicsmall yeru, Cyrillicsmall ve, Cyrillicsmall o, Cyrillicsmall er, Cyrillicsmall o, Cyril...
Title: Chromogranin B in blood serum of patients with neuroendocrine tumors.
These data collectively point out CHGB as a possible preoperative and postoperative marker for pheochromocytomas and abdominal paragangliomas with potential for aggressive behavior
Title: Molecular Profiling of Pheochromocytoma and Abdominal Paraganglioma Stratified by the PASS Algorithm Reveals Chromogranin B as Associated With Histologic Prediction of Malignant Behavior.
serum levels of CgA, CgB, and SgII were determined in Parkinson's disease patients and assessed their association with disease severity.
Title: Serum levels of chromogranins and secretogranins correlate with the progress and severity of Parkinson's disease.
the GAL3ST4 and the CHGB allele variants 23 and 48 are novel genetic loci involved in susceptibility to leprosy among female and male population, respectively
Title: Identification of novel genetic loci GAL3ST4 and CHGB involved in susceptibility to leprosy.
evidence suggests that the P413L variant of chromogranin B is not associated with amyotrophic lateral sclerosis (ALS) risk or age at ALS onset (meta-analysis).
Title: Lack of association between the P413L variant of chromogranin B and ALS risk or age at onset: a meta-analysis.
Data suggest that chromogranin B (CGB) is a promising emerging biomarker in heart failure (HF) patients with unique potential to integrate information from myocardial stress and neuro-endocrine activation.
Title: Regulation of circulating chromogranin B levels in heart failure.
Circulating chromogranin B (CgB) levels measured on Intensive Care Unit (ICU) admission provided additional prognostic information to established risk indices in acute respiratory failure (ARF) patients.
Title: Circulating chromogranin B levels in patients with acute respiratory failure: data from the FINNALI Study.
results presented here suggest that CHGB variant alleles, the rare CHGB-L413 and common CHGB-P413, may act as modifiers of ALS disease dependent on their expression levels which is higher in females because of a sex-determining region Y element in the CHGB gene promoter.
Title: Sex-dependent effects of chromogranin B P413L allelic variant as disease modifier in amyotrophic lateral sclerosis.
Compared with chromogranin A, chromogranin B may be more useful during proton pump inhibitor treatment and can detect tumors without liver metastases.
Title: Utility of chromogranin B compared with chromogranin A as a biomarker in Japanese patients with pancreatic neuroendocrine tumors.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G60229 (e-PCR)
- UniSTS:137339

SGC30394 (e-PCR)
- UniSTS:29351

D20S732 (e-PCR)
- UniSTS:12973

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables hormone activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: secretogranin-1

Names: cgB; secretogranin B; secretogranin I; sgI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.