ire-1 Endoribonuclease;Serine/threonine-protein kinase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ire-1
Official Full Name: Endoribonuclease;Serine/threonine-protein kinase
Primary source: WormBase:WBGene00002147
Locus tag: CELE_C41C4.4
See related: AllianceGenome:WB:WBGene00002147
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA endonuclease activity. Involved in several processes, including endoplasmic reticulum unfolded protein response; nematode larval development; and positive regulation of transcription by RNA polymerase II. Acts upstream of with a positive effect on IRE1-mediated unfolded protein response; intrinsic apoptotic signaling pathway by p53 class mediator; and negative regulation of multicellular organismal process. Acts upstream of with a negative effect on determination of adult lifespan. Located in neuronal cell body. Is expressed widely. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to several human genes including ERN2 (endoplasmic reticulum to nucleus signaling 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ire-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 10

Sequence:: Chromosome: II; NC_003280.10 (8112243..8124910, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UPR[ER]-immunity axis acts as physiological food evaluation system that promotes aversion behavior in sensing low-quality food.
Title: UPR(ER)-immunity axis acts as physiological food evaluation system that promotes aversion behavior in sensing low-quality food.
Inactivation of the Caenorhabditis elegans RNF-5 E3 ligase promotes IRE-1-independent ER functions.
Title: Inactivation of the Caenorhabditis elegans RNF-5 E3 ligase promotes IRE-1-independent ER functions.
Neuronal regulated ire-1-dependent mRNA decay controls germline differentiation in Caenorhabditis elegans.
Title: Neuronal regulated ire-1-dependent mRNA decay controls germline differentiation in Caenorhabditis elegans.
Alleviating chronic ER stress by p38-Ire1-Xbp1 pathway and insulin-associated autophagy in C. elegans neurons.
Title: Alleviating chronic ER stress by p38-Ire1-Xbp1 pathway and insulin-associated autophagy in C. elegans neurons.
Authors show that autophagy is modulated through the conserved IRE-1-XBP-1 axis, strongly suggesting of the importance of autophagy in maintaining cellular homeostasis during the lipid bilayer stress-induced UPR.
Title: Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress.
vitamin-D3-induced lifespan extension requires the stress response pathway genes skn-1, ire-1, and xbp-1.
Title: Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1.
Enhanced study of the role of IIS pathway and epigenetic mechanisms that regulate aging may facilitate progressive prevention and treatment of human age-related diseases.
Title: Insulin/insulin-like growth factor-1 signalling (IIS) based regulation of lifespan across species.
IRE-1 has an ancient function as a cytoplasmic sentinel that activates p38 and SKN-1(Nrf2). csteine modifications induced by ROS signals can direct proteins to adopt unexpected functions and may coordinate many cellular processes.
Title: Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response.
IRE-1 is essential for dendrite morphogenesis. Reducing Insulin/IGF1 signaling can restore normal dendrite arborization in the complete absence of functional IRE-1.
Title: Reduced Insulin/Insulin-Like Growth Factor Receptor Signaling Mitigates Defective Dendrite Morphogenesis in Mutants of the ER Stress Sensor IRE-1.
In conclusion, we identified PEK-1 as a mediator of hormesis in the mev-1 mutant of C. elegans which is induced by simultaneous inhibition of XBP-1 and its splicing activator IRE-1 and mediated through activation of the proteasome.
Title: PEK-1 is crucial for hormesis induced by inhibition of the IRE-1/XBP-1 pathway in the Caenorhabditis elegans mev-1 mutant.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C41C4.4 (e-PCR)
- UniSTS:307328

C41C4.5 (e-PCR)
- UniSTS:307329

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA endonuclease activity	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA nuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in IRE1-mediated unfolded protein response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_positive_effect IRE1-mediated unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in IRE1-mediated unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_negative_effect determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum unfolded protein response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect intrinsic apoptotic signaling pathway by p53 class mediator	EXP Inferred from Experiment more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect negative regulation of multicellular organismal process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nucleic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to topologically incorrect protein	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to topologically incorrect protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to unfolded protein	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of IRE1-TRAF2-ASK1 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: Endoribonuclease;Serine/threonine-protein kinase

NP_001254135.1

Confirmed by transcript evidence

NP_001254136.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8112243..8124910 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001267206.4 → NP_001254135.1 Serine/threonine-protein kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254135.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09499, Q8WRG0

Conserved Domains (5) summary

cd09769
Location:42 → 311

Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1

cd10422
Location:782 → 907

RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1

smart00220
Location:518 → 778

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam13360
Location:44 → 232

PQQ_2; PQQ-like domain

cl21453
Location:515 → 779

PKc_like; Protein Kinases, catalytic domain
NM_001267207.3 → NP_001254136.1 Endoribonuclease [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254136.1

Status: REVIEWED

UniProtKB/TrEMBL

E5QCG0

Conserved Domains (3) summary

cd10422
Location:440 → 565

RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1

smart00220
Location:176 → 436

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:173 → 437

PKc_like; Protein Kinases, catalytic domain