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    xpb-1 General transcription and DNA repair factor IIH helicase/translocase subunit XPB [ Caenorhabditis elegans ]

    Gene ID: 176584, updated on 9-Dec-2024

    Summary

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    Official Symbol
    xpb-1
    Official Full Name
    General transcription and DNA repair factor IIH helicase/translocase subunit XPB
    Primary source
    WormBase:WBGene00013441
    Locus tag
    CELE_Y66D12A.15
    See related
    AllianceGenome:WB:WBGene00013441
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3'-5' DNA helicase activity. Predicted to be involved in transcription initiation at RNA polymerase II promoter. Predicted to be located in nucleus. Predicted to be part of nucleotide-excision repair factor 3 complex; transcription factor TFIIH holo complex; and transcription preinitiation complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; photosensitive trichothiodystrophy 2; trichothiodystrophy; xeroderma pigmentosum; and xeroderma pigmentosum group B. Orthologous to human ERCC3 (ERCC excision repair 3, TFIIH core complex helicase subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See xpb-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (11526657..11534595)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ArgoN domain-containing protein Neighboring gene Suppressor of spindle checkpoint defect 1 Neighboring gene DUF1604 domain-containing protein;SMAP domain-containing protein;Spen family transcriptional repressor Neighboring gene Carrier domain-containing protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1. Sabatella M, et al. Cell Rep, 2021 Jan 12. PMID 33440146
    2. C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair. Thijssen KL, et al. Commun Biol, 2021 Nov 25. PMID 34824371, Free PMC Article
    3. DNA repair. O'Neil N, et al. WormBook, 2006 Jan 13. PMID 18050489, Free PMC Article
    4. Transcription mechanisms. Blackwell TK, et al. WormBook, 2006 Sep 5. PMID 18050436, Free PMC Article
    5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of nucleotide-excision repair factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    General transcription and DNA repair factor IIH helicase/translocase subunit XPB
    NP_499487.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11526657..11534595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067086.6 → NP_499487.1  General transcription and DNA repair factor IIH helicase/translocase subunit XPB [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499487.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95PZ4
      Conserved Domains (4) summary
      TIGR00603
      Location:60 → 786
      rad25; DNA repair helicase rad25
      pfam04851
      Location:322 → 485
      ResIII; Type III restriction enzyme, res subunit
      pfam13625
      Location:76 → 198
      Helicase_C_3; Helicase conserved C-terminal domain
      pfam16203
      Location:509 → 751
      ERCC3_RAD25_C; ERCC3/RAD25/XPB C-terminal helicase
    Nucleotide Protein
    Heading Accession and Version

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