unc-49 Gamma-aminobutyric acid receptor subunit beta;Neur_chan_memb domain-containing protein;Neurotransmitter-gated ion-channel ligand-binding domain-containing protein;Neurotransmitter-gated ion-channel transmembrane domain-containing protein;Uncharacterized protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-49
Official Full Name: Gamma-aminobutyric acid receptor subunit beta;Neur_chan_memb domain-containing protein;Neurotransmitter-gated ion-channel ligand-binding domain-containing protein;Neurotransmitter-gated ion-channel transmembrane domain-containing protein;Uncharacterized protein
Primary source: WormBase:WBGene00006784
Locus tag: CELE_T21C12.1
See related: AllianceGenome:WB:WBGene00006784
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GABA-A receptor activity. Predicted to contribute to chloride channel activity. Involved in gamma-aminobutyric acid signaling pathway; locomotory behavior; and regulation of backward locomotion. Located in neuromuscular junction and postsynaptic membrane. Is expressed in AVA; anal sphincter muscle; body wall musculature; and somatic nervous system. Used to study epilepsy. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See unc-49 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 26

Sequence:: Chromosome: III; NC_003281.10 (10520762..10532705)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UNC-49 is a redox-sensitive GABAA receptor that regulates the mitochondrial unfolded protein response cell nonautonomously.
Title: UNC-49 is a redox-sensitive GABA(A) receptor that regulates the mitochondrial unfolded protein response cell nonautonomously.
GABAergic synapses suppress intestinal innate immunity via insulin signaling in Caenorhabditis elegans.
Title: GABAergic synapses suppress intestinal innate immunity via insulin signaling in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T21C12.1 (e-PCR)
- UniSTS:315042

STS3-8 (e-PCR)
- UniSTS:242083

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GABA-A receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables GABA-A receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of backward locomotion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of GABA-A receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Gamma-aminobutyric acid receptor subunit beta;Neur_chan_memb domain-containing protein;Neurotransmitter-gated ion-channel ligand-binding domain-containing protein;Neurotransmitter-gated ion-channel transmembrane domain-containing protein;Uncharacterized protein

NP_001022783.1

Partially confirmed by transcript evidence

NP_001022784.1

Partially confirmed by transcript evidence

NP_001022785.1

Partially confirmed by transcript evidence

NP_001022786.1

Confirmed by transcript evidence

NP_001076648.1

Confirmed by transcript evidence

NP_001293662.1

Partially confirmed by transcript evidence

NP_001293663.1

Confirmed by transcript evidence

NP_001368253.1

Confirmed by transcript evidence

NP_001368254.1

Partially confirmed by transcript evidence

NP_001370908.1

Confirmed by transcript evidence

NP_001379283.1

Confirmed by transcript evidence

NP_001379457.1

Confirmed by transcript evidence

NP_001380139.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10520762..10532705

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027612.4 → NP_001022783.1 Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EEY3

Conserved Domains (3) summary

TIGR00860
Location:37 → 465

LIC; Cation transporter family protein

pfam02931
Location:37 → 248

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:260 → 463

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001027613.3 → NP_001022784.1 Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EFN4

Conserved Domains (3) summary

TIGR00860
Location:37 → 453

LIC; Cation transporter family protein

pfam02931
Location:37 → 248

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:260 → 451

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001027615.4 → NP_001022786.1 Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EE10

Conserved Domains (3) summary

TIGR00860
Location:37 → 423

LIC; Cation transporter family protein

pfam02931
Location:37 → 222

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:261 → 421

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001027614.4 → NP_001022785.1 Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5ECD3

Conserved Domains (3) summary

TIGR00860
Location:37 → 484

LIC; Cation transporter family protein

pfam02931
Location:37 → 248

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:260 → 482

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001392191.1 → NP_001379283.1 Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EBQ0

Conserved Domains (1) summary

TIGR00860
Location:37 → 471

LIC; Cation transporter family protein
NM_001392190.1 → NP_001380139.1 Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PBP4

Conserved Domains (1) summary

TIGR00860
Location:37 → 465

LIC; Cation transporter family protein
NM_001382981.2 → NP_001370908.1 Neurotransmitter-gated ion-channel ligand-binding domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PBB4

Conserved Domains (2) summary

cd03558
Location:167 → 181

LGIC_ECD; Cys-loop [structural motif]

cl28912
Location:60 → 187

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
NM_001306734.3 → NP_001293663.1 Neur_chan_memb domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PBC0

Conserved Domains (2) summary

pfam02931
Location:1 → 54

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:93 → 253

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001379902.1 → NP_001368254.1 Neur_chan_memb domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PRE0

Conserved Domains (1) summary

TIGR00860
Location:1 → 297

LIC; Cation transporter family protein
NM_001379903.1 → NP_001368253.1 Neur_chan_memb domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PM48

Conserved Domains (1) summary

TIGR00860
Location:1 → 303

LIC; Cation transporter family protein
NM_001306733.3 → NP_001293662.1 Uncharacterized protein CELE_T21C12.1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PEJ2

Conserved Domains (1) summary

pfam02932
Location:36 → 56

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001392193.1 → NP_001379457.1 Neurotransmitter-gated ion-channel transmembrane domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EDM9

Conserved Domains (2) summary

TIGR00860
Location:3 → 239

LIC; Cation transporter family protein

cd19049
Location:72 → 237

LGIC_TM_anion; transmembrane domain of anionic Cys-loop neurotransmitter-gated ion channels, includes GABAAR, GlyR and GluCl
NM_001083179.4 → NP_001076648.1 Neurotransmitter-gated ion-channel transmembrane domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q0PDK2

Conserved Domains (2) summary

cd03559
Location:24 → 105

LGIC_TM; TM3 helix [structural motif]

cl38911
Location:1 → 130

LGIC_TM; transmembrane domain of Cys-loop neurotransmitter-gated ion channels